Trm7-32 tRNA methyltransferase 7-32 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trm7-32provided by FlyBase
Official Full Name: tRNA methyltransferase 7-32provided by FlyBase
Primary source: FLYBASE:FBgn0038471
Locus tag: Dmel_CG5220
See related: AllianceGenome:FB:FBgn0038471
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5220; Dm TRM7; Dmel\CG5220; dTrm7_32; Trm7_32
Summary: Enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity. Involved in neurogenesis and tRNA nucleoside ribose methylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Used to study non-syndromic X-linked intellectual disability 9. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17040682..17041895)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12866404..12867617)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA (guanine) methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tRNA nucleoside ribose methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA nucleoside ribose methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

NP_650590.1

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The following sections contain reference sequences that belong to a specific genome build. Explain