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    Polr2B RNA polymerase II subunit B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2Bprovided by FlyBase
    Official Full Name
    RNA polymerase II subunit Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262955
    Locus tag
    Dmel_CG3180
    See related
    AllianceGenome:FB:FBgn0262955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3180; Dmel\CG3180; DmRP140; H5; II; l(3)RplII140; pol II; Pol II; Pol IIc; polII; PolII; PolIIc; RNA pol II; RNA Pol II; RNA Pol II 140; RNA Pol IIc; RNA polII; RNAP; RNAP II; RNApolII; RP140; Rpb2; RPB2; RPB2_DROME; RpII140; RPII140; rpII140/wimp; RpII140[wimp]; RpIl140; Rpll140; wimp
    Summary
    Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Part of RNA polymerase II, core complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human POLR2B (RNA polymerase II subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr2B in Genome Data Viewer
    Location:
    88A9-88A9; 3-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14125791..14130111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9951513..9955833)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Abelson interacting protein Neighboring gene twinfilin Neighboring gene upstream of RpII140 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a nucleic acid-binding region within the largest subunit of Drosophila melanogaster RNA polymerase II. Kontermann RE, et al. Protein Sci, 1993 Feb. PMID 8443600, Free PMC Article
    2. Analysis of the promoter region of the housekeeping gene DmRP140 by sequence comparison of Drosophila melanogaster and Drosophila virilis. Sitzler S, et al. Gene, 1991 Sep 15. PMID 1937028
    3. RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase. Falkenburg D, et al. J Mol Biol, 1987 Jun 20. PMID 3116266
    4. Identifying a transcription factor interaction site on RNA polymerase II. Skantar AM, et al. Gene Expr, 1995. PMID 7488860, Free PMC Article
    5. Transcription of DmRP140, the gene coding for the second-largest subunit of RNA polymerase II. Wiedemann M, et al. Biochim Biophys Acta, 1997 Feb 28. PMID 9061024

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase II subunit B
    Names
    150kDa polypeptide
    CG3180-PA
    CG3180-PB
    Pol II
    Polr2B-PA
    Polr2B-PB
    RNA pol II second largest subunit
    RNA polymerase II
    RNA polymerase II 140 kD subunit
    RNA polymerase II 140kD subunit
    RNA polymerase II second largest subunit
    RNA polymerase IIc
    RNA polymerase subunit IIc
    RNA polymeraseII-140 kd subunit
    Rpb2
    subunit IIc of RNA Pol II
    wimp
    NP_001287323.1
    NP_476706.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14125791..14130111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300394.1 → NP_001287323.1  RNA polymerase II subunit B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08266, Q04155, Q95027, Q9VFM7
      UniProtKB/TrEMBL
      A0A0B4LI86
      Conserved Domains (1) summary
      PRK08565
      Location:28 → 1176
      PRK08565; DNA-directed RNA polymerase subunit B; Provisional

    2. NM_057358.4 → NP_476706.1  RNA polymerase II subunit B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476706.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08266, Q04155, Q95027, Q9VFM7
      UniProtKB/TrEMBL
      A0A0B4LI86
      Related
      FBpp0082353
      Conserved Domains (1) summary
      PRK08565
      Location:28 → 1176
      PRK08565; DNA-directed RNA polymerase subunit B; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LI86 A0A0B4LI86
    P08266.2 P08266

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