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    Rbpn-5 Rabaptin-5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbpn-5provided by FlyBase
    Official Full Name
    Rabaptin-5provided by FlyBase
    Primary source
    FLYBASE:FBgn0034585
    Locus tag
    Dmel_CG4030
    See related
    AllianceGenome:FB:FBgn0034585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4030; Dmel\CG4030
    Summary
    Enables small GTPase binding activity. Predicted to be involved in endocytosis. Located in early endosome. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and longitudinal visceral muscle primordium. Orthologous to human RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbpn-5 in Genome Data Viewer
    Location:
    57B19-57B19; 2-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21088386..21091004, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16975891..16978509, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44703 Neighboring gene antisense RNA:CR44704 Neighboring gene Chitinase 9 Neighboring gene uncharacterized protein Neighboring gene Trehalase Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein Neighboring gene king tubby Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster. Thomas C, et al. Dev Biol, 2014 Jan 1. PMID 24104056, Free PMC Article
    2. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    3. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, et al. Nat Cell Biol, 2017 Dec. PMID 29084199
    4. Endolysosomal trafficking controls yolk granule biogenesis in vitellogenic Drosophila oocytes. Yu Y, et al. PLoS Genet, 2024 Feb. PMID 38315726, Free PMC Article
    5. Oncogenic programmes and Notch activity: an 'organized crime'? Dominguez M. Semin Cell Dev Biol, 2014 Apr. PMID 24780858

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rabaptin-5
    Names
    CG4030-PA
    Rabaptin5
    Rbpn-5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21088386..21091004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137701.3 → NP_611545.1  Rabaptin-5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RK4, Q9W2M0
      Related
      FBpp0071563
      Conserved Domains (4) summary
      cd15739
      Location:557 → 629
      FYVE_RABE_unchar; FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria
      pfam00901
      Location:336 → 473
      Orbi_VP5; Orbivirus outer capsid protein VP5
      pfam03528
      Location:37 → 374
      Rabaptin; Rabaptin
      pfam09311
      Location:256 → 555
      Rab5-bind; Rabaptin-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2M0 Q9W2M0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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