Mcr Macroglobulin complement-related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mcrprovided by FlyBase
Official Full Name: Macroglobulin complement-relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0267488
Locus tag: Dmel_CG7586
See related: AllianceGenome:FB:FBgn0267488
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha-2-Mrp; anon-28DE; CG7586; Dmel\CG7586; DmTEP6; dTEPVI; E(br)155; luf; mcr; Tep6; TEP6; TEP6mel; TepVI
Summary: Enables structural molecule activity. Involved in several processes, including embryonic development via the syncytial blastoderm; regulation of tube length, open tracheal system; and septate junction assembly. Located in several cellular components, including apicolateral plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; crop; embryonic/larval salivary gland; epithelium; and gut section. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); lung disease (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3) and C5 (complement C5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 28E1-28E3; 2-30 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8074117..8082982, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8074117..8082982, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of Tep2 or Tep6 affects phagocytosis and melanization in flies infected with Photorhabdus.
Title: The distinct function of Tep2 and Tep6 in the immune defense of Drosophila melanogaster against the pathogen Photorhabdus.
The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila.
Title: The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila.
Mcr plays an essential role during embryonic development in septate junction organization and function.
Title: Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila.
Mcr is secreted by D. melanogaster, it binds specifically to the surface of C. albicans, and that it promotes its subsequent phagocytosis. Mcr is closely related to the four Drosophila thioester proteins (Teps).
Title: Identification of Drosophila gene products required for phagocytosis of Candida albicans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis, recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: macroglobulin complement-related

Names: CG7586-PA; E(br)155; Mcr-PA; TEP; Tep6; alpha-2-macroglobulin related; enhancer of broad; enhancer of broad 155; luftschlange; macroglobulin complement related; thiolester containing protein VI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8074117..8082982 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079949.3 → NP_524688.1 macroglobulin complement-related [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524688.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VLT3

Related

FBpp0079165

Conserved Domains (7) summary

cd00112
Location:886 → 913

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00207
Location:940 → 1030

A2M; Alpha-2-macroglobulin family

pfam01835
Location:232 → 332

A2M_N; MG2 domain

pfam07677
Location:1607 → 1695

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1226 → 1492

A2M_comp; A-macroglobulin complement component

pfam07703
Location:669 → 799

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

cl08267
Location:1177 → 1490

ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...