ben bendless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: benprovided by FlyBase
Official Full Name: bendlessprovided by FlyBase
Primary source: FLYBASE:FBgn0000173
Locus tag: Dmel_CG18319
See related: AllianceGenome:FB:FBgn0000173
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.242; Ben; BEN; bend; Bend; Bendless; CG18319; Dmel\CG18319; nj-262; ubc13; Ubc13; UBC13; UbcD3
Summary: Enables ubiquitin conjugating enzyme activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including grooming behavior; nervous system development; and positive regulation of signal transduction. Located in nucleus and perinuclear region of cytoplasm. Part of UBC13-MMS2 complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N) and UBE2NL (ubiquitin conjugating enzyme E2 N like (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12D2-12D2; 1-47 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13996345..13999805)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13890378..13893838)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
Title: Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
the Bendless (Ben)/dUev1a ubiquitin E2 complex is an essential regulator of Src42A-induced, JNK-mediated cell migration.
Title: Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila.
This study suggests a role for ben in the MB during olfactory memory formation. Also provide evidence that BEN interacts genetically in both synaptic transmission and LTM formation with SCAMP.
Title: ben Functions with scamp during synaptic transmission and long-term memory formation in Drosophila.
Bendless functions as a novel developmental switch that permits the transition from axonal growth and incipient synapse formation to synaptic growth and maturation in the central nervous system.
Title: A mechanism distinct from highwire for the Drosophila ubiquitin conjugase bendless in synaptic growth and maturation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in jump response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postreplication repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of UBC13-MMS2 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bendless

Names: CG18319-PA; CG18319-PB; CG18319-PC; CG18319-PD; CG18319-PE; ben-PA; ben-PB; ben-PC; ben-PD; ben-PE; nonjumper-262

NP_001162752.1

EC 2.3.2.23

NP_001245663.1

EC 2.3.2.23

NP_001259540.1

EC 2.3.2.23

NP_001259541.1

EC 2.3.2.23

NP_511150.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13996345..13999805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258734.2 → NP_001245663.1 bendless, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245663.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A9YHJ7, P35128, Q9VY67

UniProtKB/TrEMBL

E1JJN1

Conserved Domains (1) summary

cl00154
Location:3 → 149

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_078595.3 → NP_511150.1 bendless, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511150.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A9YHJ7, P35128, Q9VY67

UniProtKB/TrEMBL

E1JJN1

Related

FBpp0073686

Conserved Domains (1) summary

cl00154
Location:3 → 149

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001169281.2 → NP_001162752.1 bendless, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162752.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A9YHJ7, P35128, Q9VY67

UniProtKB/TrEMBL

E1JJN1

Conserved Domains (1) summary

cl00154
Location:3 → 149

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001272611.2 → NP_001259540.1 bendless, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259540.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A9YHJ7, P35128, Q9VY67

UniProtKB/TrEMBL

E1JJN1

Conserved Domains (1) summary

cl00154
Location:3 → 149

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001272612.2 → NP_001259541.1 bendless, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259541.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A9YHJ7, P35128, Q9VY67

UniProtKB/TrEMBL

E1JJN1

Conserved Domains (1) summary

cl00154
Location:3 → 149

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...