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    fand fandango [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fandprovided by FlyBase
    Official Full Name
    fandangoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033859
    Locus tag
    Dmel_CG6197
    See related
    AllianceGenome:FB:FBgn0033859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6197; Dmel\CG6197; Fand; fas; l(2)05488; l(2)5488; Prp5; Xab2; XAB2
    Summary
    Involved in Malpighian tubule morphogenesis; RNA splicing; and cardioblast cell fate determination. Part of Prp19 complex. Orthologous to human XAB2 (XPA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fand in Genome Data Viewer
    Location:
    50B4-50B4; 2-68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13593644..13596557)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9481149..9484062)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44366 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia. Myat MM, et al. Development, 2000 Feb. PMID 10648227
    2. The role of cell adhesion molecules in Drosophila heart morphogenesis: faint sausage, shotgun/DE-cadherin, and laminin A are required for discrete stages in heart development. Haag TA, et al. Dev Biol, 1999 Apr 1. PMID 10075841
    3. faint sausage encodes a novel extracellular protein of the immunoglobulin superfamily required for cell migration and the establishment of normal axonal pathways in the Drosophila nervous system. Lekven AC, et al. Development, 1998 Jul. PMID 9636088
    4. Flanking duplications and deletions associated with P-induced male recombination in Drosophila. Preston CR, et al. Genetics, 1996 Dec. PMID 8978050, Free PMC Article
    5. Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila. Sauerwald J, et al. Development, 2017 Feb 15. PMID 28087625

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardioblast cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in generation of catalytic spliceosome for first transesterification step IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    fandango
    Names
    CG6197-PA
    complementation group 7
    faint sausage
    fand-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13593644..13596557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137047.3 → NP_610891.1  fandango [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610891.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9G2, C3KGI3
      Related
      FBpp0086749
      Conserved Domains (2) summary
      COG3063
      Location:443 → 617
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      sd00006
      Location:432 → 460
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9G2.1 A1Z9G2

    Gene LinkOut

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