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    Hsl Hormone-sensitive lipase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37289, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hslprovided by FlyBase
    Official Full Name
    Hormone-sensitive lipaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034491
    Locus tag
    Dmel_CG11055
    See related
    AllianceGenome:FB:FBgn0034491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A; anon-56Ea; CG11055; dhsl; dHSL; Dmel\CG11055; DmHSL; hsl; HSL
    Summary
    Predicted to enable monoacylglycerol lipase activity; sterol ester esterase activity; and triacylglycerol lipase activity. Involved in triglyceride mobilization. Located in cytosol. Is active in lipid droplet. Is expressed in adult head; embryonic/larval gut; and organism. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hsl in Genome Data Viewer
    Location:
    56F11-56F11; 2-90 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20257650..20261726)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16145155..16149231)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Arginyltransferase 1 Neighboring gene Proliferating cell nuclear antigen Neighboring gene plutonium

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success. Heier C, et al. Elife, 2021 Feb 4. PMID 33538247, Free PMC Article
    2. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. Axton JM, et al. EMBO J, 1994 Jan 15. PMID 8313891, Free PMC Article
    3. Membrane attachment and structure models of lipid storage droplet protein 1. Lin P, et al. Biochim Biophys Acta, 2014 Mar. PMID 24333382, Free PMC Article
    4. Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization. Bi J, et al. J Cell Sci, 2012 Aug 1. PMID 22505614
    5. RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults. Azuma M, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30720195

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success.
      Title: Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride mobilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hormone-sensitive lipase
    Names
    CG11055-PA
    CG11055-PB
    CG11055-PC
    Hormone-sensitive lipase ortholog
    Hsl-PA
    Hsl-PB
    Hsl-PC
    hormone sensitive lipase
    transcription unit A
    NP_611463.1
    NP_725941.1
    NP_725942.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20257650..20261726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137619.3 → NP_611463.1  Hormone-sensitive lipase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR83
      Related
      FBpp0085582
      Conserved Domains (3) summary
      COG0657
      Location:350 → 537
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:51 → 376
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:395 → 539
      Abhydrolase; alpha/beta hydrolases

    2. NM_166381.2 → NP_725941.1  Hormone-sensitive lipase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR83
      Related
      FBpp0085583
      Conserved Domains (3) summary
      COG0657
      Location:350 → 537
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:51 → 376
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:395 → 539
      Abhydrolase; alpha/beta hydrolases

    3. NM_166382.2 → NP_725942.1  Hormone-sensitive lipase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR83
      Related
      FBpp0085584
      Conserved Domains (3) summary
      COG0657
      Location:350 → 537
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:51 → 376
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:395 → 539
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JR83 Q7JR83
    Q960T4 Q960T4

    Gene LinkOut

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