Nct Nicastrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nctprovided by FlyBase
Official Full Name: Nicastrinprovided by FlyBase
Primary source: FLYBASE:FBgn0039234
Locus tag: Dmel_CG7012
See related: AllianceGenome:FB:FBgn0039234
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: agro; CG7012; Dmel\CG7012; dNct; nct; nic; Nic; S5A; ST96B
Summary: Involved in several processes, including amyloid-beta formation; lateral inhibition; and membrane protein proteolysis. Located in late endosome and recycling endosome. Part of gamma-secretase complex. Is expressed in several structures, including adult head; central brain primordium; ganglia; and ventral nerve cord primordium. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96B1-96B1; 3-86 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24851601..24854869)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20677323..20680591)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nct is required for neuronal survival during aging and normal lifespan.
Title: An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.
Title: Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.
Nicastrin is essential to early photoreceptor neuron development
Title: Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye.
presenilin, nicastrin, APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes
Title: Gamma-secretase is a functional component of phagosomes.
Co-expression of Drosophila Pen-2 with Aph-1 and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity
Title: The role of presenilin cofactors in the gamma-secretase complex.
the proper assembly of the Aph-1.nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 functions as a stabilizing scaffold in the assembly of this complex
Title: Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.
Aph-1 and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly.
Title: Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch receptor processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch receptor processing, ligand-dependent	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of gamma-secretase complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-secretase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nicastrin

Names: CG7012-PA; CG7012-PC; CG7012-PD; CG7012-PE; Nct-PA; Nct-PC; Nct-PD; Nct-PE; agoraphobic; dNicastrin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24851601..24854869

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170242.2 → NP_001163713.1 nicastrin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163713.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VC27

UniProtKB/TrEMBL

E1JIV8

Conserved Domains (1) summary

cd03881
Location:164 → 471

M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex
NM_001276003.1 → NP_001262932.1 nicastrin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262932.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHG2

Conserved Domains (1) summary

cd03881
Location:164 → 471

M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex
NM_206568.4 → NP_996291.2 nicastrin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996291.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KS07

Conserved Domains (1) summary

cd03881
Location:164 → 471

M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex
NM_143040.5 → NP_651297.2 nicastrin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651297.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VC27

UniProtKB/TrEMBL

E1JIV8

Related

FBpp0084083

Conserved Domains (1) summary

cd03881
Location:164 → 471

M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex