Parg Poly(ADP-ribose) glycohydrolase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pargprovided by FlyBase
Official Full Name: Poly(ADP-ribose) glycohydrolaseprovided by FlyBase
Primary source: FLYBASE:FBgn0023216
Locus tag: Dmel_CG2864
See related: AllianceGenome:FB:FBgn0023216
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2864; Dmel\CG2864; dParg; EG:114E2.1; HD10914; parg; PARG
Summary: Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in several processes, including Cajal body organization; female germ-line stem cell population maintenance; and regulation of gene expression. Located in nucleoplasm. Is active in site of DNA damage. Used to study stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3E2-3E2; 1-4 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3668837..3671502, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3562870..3565535, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARG Protein Regulation Roles in Drosophila Longevity Control.
Title: PARG Protein Regulation Roles in Drosophila Longevity Control.
loss of function mutant exhibits lethality in the larval stages at the normal development temperature of 25 degrees C
Title: Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ADP-ribosylserine hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(ADP-ribose) glycohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(ADP-ribose) glycohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(ADP-ribose) glycohydrolase activity	IEA Inferred from Electronic Annotation more info
enables poly(ADP-ribose) glycohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP generation from poly-ADP-D-ribose	IBA Inferred from Biological aspect of Ancestor more info
involved_in Cajal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-sugar metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA repair	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Poly(ADP-ribose) glycohydrolase

Names: CG2864-PB; CG2864-PC; Parg-PB; Parg-PC; Poly(ADP-ribose)glycohydrolase; Poly(ADPribose) glyco-hydrolase

NP_001245511.1

EC 3.2.1.143

NP_477321.2

EC 3.2.1.143

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3668837..3671502 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057973.4 → NP_477321.2 Poly(ADP-ribose) glycohydrolase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477321.2

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NEU9, O46043, Q960N8

Conserved Domains (1) summary

pfam05028
Location:155 → 492

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
NM_001258582.2 → NP_001245511.1 Poly(ADP-ribose) glycohydrolase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245511.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NEU9, O46043, Q960N8

Conserved Domains (1) summary

pfam05028
Location:155 → 492

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)