Su(var)3-3 Suppressor of variegation 3-3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(var)3-3provided by FlyBase
Official Full Name: Suppressor of variegation 3-3provided by FlyBase
Primary source: FLYBASE:FBgn0260397
Locus tag: Dmel_CG17149
See related: AllianceGenome:FB:FBgn0260397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17149; dLsd1; dLSD1; Dmel/HDM; Dmel/LSD1; Dmel\CG17149; Dmel\LSD1; Hdm; lsd1; Lsd1; LSD1; Su(Var)3-3; SU(VAR)3-3; Su-var(3)3; Suvar(3)3
Summary: Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Involved in imaginal disc-derived wing vein specification; oogenesis; and regulation of gene expression. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including germarium; germline cell; somatic cell of ovariole; and wing. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 77A3-77A3; 3-47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20226381..20230250)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20219481..20223350)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified lysine-specific demethylase 1 (lsd1) and CoRest as differentiation regulators
Title: The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.
Lsd1 functions to repress decapentaplegic (dpp) expression in adult germaria
Title: Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary.
found that the Lysine Specific Demethylase 1 gene (lsd1) was important for the proper cell type-specific development of wing patterning
Title: Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development.
Title: Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm0956 (e-PCR)
- UniSTS:44483

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables histone H3K4 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K4 demethylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin boundary formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: suppressor of variegation 3-3

Names: CG17149-PA; CG17149-PB; CG17149-PC; Su(var)3-3-PA; Su(var)3-3-PB; Su(var)3-3-PC; flavoprotein; histone demethylase; histone lysine-specific demethylase 1; lysine-specific demethylase 1

NP_001262100.1

EC 1.-.-.-

EC 1.14.99.66

NP_649194.1

EC 1.-.-.-

EC 1.14.99.66

NP_730497.1

EC 1.-.-.-

EC 1.14.99.66

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20226381..20230250

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140937.3 → NP_649194.1 suppressor of variegation 3-3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649194.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0E8C9, Q9VW97

UniProtKB/TrEMBL

B7Z0G7

Related

FBpp0074594

Conserved Domains (3) summary

pfam01593
Location:274 → 824

Amino_oxidase; Flavin containing amine oxidoreductase

pfam04433
Location:165 → 250

SWIRM; SWIRM domain

pfam13450
Location:269 → 327

NAD_binding_8; NAD(P)-binding Rossmann-like domain
NM_168835.2 → NP_730497.1 suppressor of variegation 3-3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730497.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0E8C9, Q9VW97

UniProtKB/TrEMBL

B7Z0G7

Related

FBpp0074595

Conserved Domains (3) summary

pfam01593
Location:274 → 824

Amino_oxidase; Flavin containing amine oxidoreductase

pfam04433
Location:165 → 250

SWIRM; SWIRM domain

pfam13450
Location:269 → 327

NAD_binding_8; NAD(P)-binding Rossmann-like domain
NM_001275171.1 → NP_001262100.1 suppressor of variegation 3-3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262100.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFR5

Conserved Domains (3) summary

pfam01593
Location:254 → 804

Amino_oxidase; Flavin containing amine oxidoreductase

pfam04433
Location:165 → 230

SWIRM; SWIRM domain

pfam13450
Location:249 → 307

NAD_binding_8; NAD(P)-binding Rossmann-like domain