apt apontic [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aptprovided by FlyBase
Official Full Name: aponticprovided by FlyBase
Primary source: FLYBASE:FBgn0015903
Locus tag: Dmel_CG5393
See related: AllianceGenome:FB:FBgn0015903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3041; Apt; APT; CG5393; Dmel\CG5393; l(2)03041; l(2)06369; l(2)09049; l(2)59Ea; l(2)k11531; tdf; TDF; TDF/APT; Tdp
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and mRNA 3'-UTR binding activity. Involved in several processes, including behavioral response to ethanol; epithelial cell migration; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including anlage in statu nascendi; germline cell; glial cell; head segment; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59F1-59F4; 2-104 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23564891..23599526)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19452414..19487049)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apt-mediated expression of Hh and cyclin E can direct proliferation of Hh-expressing cells and simultaneous growth, patterning and differentiation of Hh-recipient cells.
Title: Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning.
These findings reveal a Gcm-Apt-CycE axis that regulates neuroblast and glia cell differentiation.
Title: The transcriptional factor Apt regulates neuroblast differentiation through activating CycE expression.
Apt acts as a core component of a STAT-regulatory circuit to prevent stem cell overpopulation and allow stem cell maturation.
Title: Apontic regulates somatic stem cell numbers in Drosophila testes.
Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin E during eye development.
Title: Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin E during eye development.
APT directly regulates Socs36E transcriptionally during ovarian development.
Title: Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
The work presented here identifies two genes, apt and crz, which mediate the fly's sensitivity to ethanol-induced sedation.
Title: A small group of neurosecretory cells expressing the transcriptional regulator apontic and the neuropeptide corazonin mediate ethanol sedation in Drosophila.
The data suggest that a regulatory circuit between STAT, APT, and SLBO functions to convert an initially graded signal into an all-or-nothing activation of JAK/STAT and thus to proper cell specification and migration.
Title: Feedback inhibition of Jak/STAT signaling by apontic is required to limit an invasive cell population.
MBF1 was found to form a ternary complex including MBF1, TATA-binding protein (TBP) and the bZIP protein Tracheae Defective (TDF)/Apontic.
Title: Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0899 (e-PCR)
- UniSTS:37362

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of oskar mRNA translation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of oskar mRNA translation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in posterior head segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: apontic

Names: CG5393-PA; CG5393-PB; CG5393-PC; CG5393-PD; CG5393-PE; CG5393-PF; apt-PA; apt-PB; apt-PC; apt-PD; apt-PE; apt-PF; trachea defective; tracheae defective; tracheal defective