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    Sym Symplekin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Symprovided by FlyBase
    Official Full Name
    Symplekinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037371
    Locus tag
    Dmel_CG2097
    See related
    AllianceGenome:FB:FBgn0037371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2097; Dmel\CG2097; dSymp; Symp; symplekin
    Summary
    Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in histone locus body and tricellular tight junction. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in organism and spermatozoon. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sym in Genome Data Viewer
    Location:
    83C1-83C2; 3-47.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5738178..5742476, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1563900..1568198, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MLF1-adaptor molecule Neighboring gene Decapping enzyme, scavenger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors propose a model in which the core cleavage complex formation is mediated by CPSF73, CPSF100, and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.
      Title: In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex.
    2. This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
      Title: Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions.
    3. Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.
      Title: Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tricellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    symplekin
    Names
    CG2097-PA
    Sym-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5738178..5742476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141323.2 → NP_649580.1  symplekin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSU4, Q9VNH4
      Related
      FBpp0078372
      Conserved Domains (2) summary
      pfam11935
      Location:115 → 345
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:887 → 1067
      Symplekin_C; Symplekin tight junction protein C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSU4.1 Q8MSU4

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