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    Noc2 Nucleolar complex protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Noc2provided by FlyBase
    Official Full Name
    Nucleolar complex protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032925
    Locus tag
    Dmel_CG9246
    See related
    AllianceGenome:FB:FBgn0032925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9246; Dmel\CG9246; NOC2?
    Summary
    Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and ribosomal large subunit biogenesis. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Noc2 in Genome Data Viewer
    Location:
    39A7-39A7; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21163641..21166090)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21163641..21166090)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 6 Neighboring gene Coenzyme Q3 Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of nucleolar NOC1 leads to the accumulation of pre-rRNAs and induces Xrp1, affecting growth and resulting in cell competition. Destefanis F, et al. J Cell Sci, 2022 Dec 1. PMID 36314272, Free PMC Article
    2. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu P, et al. Development, 2001 Dec. PMID 11748144
    3. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Abramov YA, et al. Genetics, 2016 Jan. PMID 26500261, Free PMC Article
    4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    5. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc1p-Noc2p complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of Noc2p-Noc3p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc2p-Noc3p complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 2
    Names
    CG9246-PA
    Noc2-PA
    nucleolar complex protein-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21163641..21166090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136251.4 → NP_610095.1  nucleolar complex protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIF0
      Related
      FBpp0081001
      Conserved Domains (1) summary
      pfam03715
      Location:344 → 641
      Noc2; Noc2p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIF0.1 Q9VIF0

    Gene LinkOut

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