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    Acot4 acyl-CoA thioesterase 4 [ Mus musculus (house mouse) ]

    Gene ID: 171282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acot4provided by MGI
    Official Full Name
    acyl-CoA thioesterase 4provided by MGI
    Primary source
    MGI:MGI:2159621
    See related
    Ensembl:ENSMUSG00000052392 AllianceGenome:MGI:2159621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pte1b; Pte2b; PTE-Ib; B430212I04Rik
    Summary
    Enables fatty acyl-CoA hydrolase activity. Involved in dicarboxylic acid metabolic process; short-chain fatty acid metabolic process; and succinyl-CoA metabolic process. Located in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and respiratory system. Orthologous to human ACOT4 (acyl-CoA thioesterase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 13.6), kidney adult (RPKM 12.4) and 14 other tissues See more
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    Genomic context

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    See Acot4 in Genome Data Viewer
    Location:
    12 D1; 12 39.01 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84084028..84091497)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84037254..84044723)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32720 Neighboring gene acyl-CoA thioesterase 2 Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene predicted gene, 40474 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene acyl-CoA thioesterase 3 Neighboring gene acyl-CoA thioesterase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. Westin MA, et al. J Biol Chem, 2005 Nov 18. PMID 16141203
    2. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
    3. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. Hunt MC, et al. J Biol Chem, 1999 Nov 26. PMID 10567408
    4. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
    5. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, et al. Cell, 2012 Dec 21. PMID 23260145

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acyl-CoA hydrolase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables succinyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dicarboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dicarboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dicarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dicarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in saturated monocarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in saturated monocarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in short-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in short-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unsaturated monocarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in unsaturated monocarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal succinyl-coenzyme A thioesterase
    Names
    PTE-2b
    acyl-coenzyme A thioesterase 4
    peroxisomal acyl coenzyme A thioester hydrolase Ib
    peroxisomal acyl-CoA thioesterase 2B
    peroxisomal long-chain acyl-CoA thioesterase Ib
    NP_599008.3
    XP_017170456.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134247.3 → NP_599008.3  peroxisomal succinyl-coenzyme A thioesterase

      See identical proteins and their annotated locations for NP_599008.3

      Status: VALIDATED

      Source sequence(s)
      AC133183, AK046630, BC113185
      Consensus CDS
      CCDS26035.1
      UniProtKB/Swiss-Prot
      Q8BJQ1, Q8BL20, Q8BWN8, Q9QYR8
      UniProtKB/TrEMBL
      Q14DI6
      Related
      ENSMUSP00000021652.4, ENSMUST00000021652.5
      Conserved Domains (3) summary
      pfam08840
      Location:204 → 412
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:137 → 253
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84084028..84091497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314967.3 → XP_017170456.1  peroxisomal succinyl-coenzyme A thioesterase isoform X1

      Conserved Domains (1) summary
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    RNA

    1. XR_003949990.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWN8.1 GenPept UniProtKB/Swiss-Prot:Q8BWN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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