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    Cimip4 ciliary microtubule inner protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 73376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cimip4provided by MGI
    Official Full Name
    ciliary microtubule inner protein 4provided by MGI
    Primary source
    MGI:MGI:1920626
    See related
    Ensembl:ENSMUSG00000062154 AllianceGenome:MGI:1920626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ean57; Tex33; 1700061J05Rik
    Summary
    Located in sperm flagellum. Orthologous to human CIMIP4 (ciliary microtubule inner protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 328.3) See more
    Orthologs
    human all
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    Genomic context

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    See Cimip4 in Genome Data Viewer
    Location:
    15 E1; 15 37.45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78262600..78280112, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78378400..78395912, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene microRNA 7676-1 Neighboring gene colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2 Neighboring gene STARR-seq mESC enhancer starr_39143 Neighboring gene thiosulfate sulfurtransferase, mitochondrial Neighboring gene predicted gene, 52185 Neighboring gene mercaptopyruvate sulfurtransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spermatogenesis is normal in Tex33 knockout mice. Zhu Z, et al. PeerJ, 2020. PMID 32821546, Free PMC Article
    2. Testis-expressed protein 33 is not essential for spermiogenesis and fertility in mice. Xia M, et al. Mol Med Rep, 2021 May. PMID 33760102, Free PMC Article
    3. CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity. Park S, et al. Biol Reprod, 2020 Aug 4. PMID 32561905, Free PMC Article
    4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130090

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary microtubule inner protein 4
    Names
    protein EAN57
    testis expressed 33
    testis-expressed protein 33
    testis-expressed sequence 33 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163612.2 → NP_001157084.1  ciliary microtubule inner protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001157084.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK006856, BY105066, CJ047876
      Consensus CDS
      CCDS49665.1
      UniProtKB/Swiss-Prot
      Q9D9J2
      UniProtKB/TrEMBL
      Q3KNN2
      Related
      ENSMUSP00000073984.8, ENSMUST00000074380.14
      Conserved Domains (1) summary
      pfam15400
      Location:128 → 265
      TEX33; Testis-expressed sequence 33 protein family

    2. NM_001163613.1 → NP_001157085.1  ciliary microtubule inner protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL583893
      Consensus CDS
      CCDS49664.1
      UniProtKB/TrEMBL
      E9QA37
      Related
      ENSMUSP00000130849.2, ENSMUST00000169575.2
      Conserved Domains (1) summary
      pfam15400
      Location:103 → 240
      TEX33; Testis-expressed sequence 33 protein family

    3. NM_028522.1 → NP_082798.1  ciliary microtubule inner protein 4 isoform 1

      See identical proteins and their annotated locations for NP_082798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK006856, CJ047876
      Consensus CDS
      CCDS49665.1
      UniProtKB/Swiss-Prot
      Q9D9J2
      UniProtKB/TrEMBL
      Q3KNN2
      Related
      ENSMUSP00000133264.2, ENSMUST00000165170.8
      Conserved Domains (1) summary
      pfam15400
      Location:128 → 265
      TEX33; Testis-expressed sequence 33 protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78262600..78280112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9J2.1 GenPept UniProtKB/Swiss-Prot:Q9D9J2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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