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    Fstl5 follistatin-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 213262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fstl5provided by MGI
    Official Full Name
    follistatin-like 5provided by MGI
    Primary source
    MGI:MGI:2442179
    See related
    Ensembl:ENSMUSG00000034098 AllianceGenome:MGI:2442179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130207J01Rik
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation and regulation of BMP signaling pathway. Predicted to be active in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; limb; and retina. Orthologous to human FSTL5 (follistatin like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 5.6), whole brain E14.5 (RPKM 4.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fstl5 in Genome Data Viewer
    Location:
    3 E3; 3 34.04 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (75981582..76617317)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (76074275..76710010)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1260 Neighboring gene golgi integral membrane protein 4 Neighboring gene STARR-positive B cell enhancer mm9_chr3:75805184-75805484 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene VISTA enhancer mm1370 Neighboring gene STARR-seq mESC enhancer starr_07975 Neighboring gene STARR-seq mESC enhancer starr_07976 Neighboring gene STARR-seq mESC enhancer starr_07977 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07978 Neighboring gene predicted gene, 23644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system. Masuda T, et al. Congenit Anom (Kyoto), 2014 Feb. PMID 24588779
    2. Genetic association and characterization of FSTL5 in isolated clubfoot. Khanshour AM, et al. Hum Mol Genet, 2021 Jan 21. PMID 33105483, Free PMC Article
    3. Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes. Markenscoff-Papadimitriou E, et al. Cell Rep, 2021 Dec 7. PMID 34879283, Free PMC Article
    4. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
    5. Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Li X, et al. Physiol Genomics, 2007 May 11. PMID 17299133

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Restricted expression in the olfactory system suggests a possible role for Fstl5 in maintaining odor perception
      Title: Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    follistatin-related protein 5
    Names
    follistatin-like protein 5
    m-D/Bsp120I 1-2
    ollistatin-like 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253719.1 → NP_001240648.1  follistatin-related protein 5 precursor

      See identical proteins and their annotated locations for NP_001240648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK046070, BC075640
      Consensus CDS
      CCDS38455.1
      UniProtKB/Swiss-Prot
      Q80TG3, Q8BFR2, Q8C4T3
      UniProtKB/TrEMBL
      Q3UUI4
      Related
      ENSMUSP00000125393.2, ENSMUST00000160261.8
      Conserved Domains (4) summary
      cd05736
      Location:358 → 433
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
      cd00104
      Location:93 → 133
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00096
      Location:266 → 323
      Ig; Immunoglobulin domain
      pfam13499
      Location:182 → 243
      EF-hand_7; EF-hand domain pair

    2. NM_178673.4 → NP_848788.2  follistatin-related protein 5 precursor

      See identical proteins and their annotated locations for NP_848788.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      BB646895, BC075640
      Consensus CDS
      CCDS38455.1
      UniProtKB/Swiss-Prot
      Q80TG3, Q8BFR2, Q8C4T3
      UniProtKB/TrEMBL
      Q3UUI4
      Related
      ENSMUSP00000038506.9, ENSMUST00000038364.15
      Conserved Domains (4) summary
      cd05736
      Location:358 → 433
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
      cd00104
      Location:93 → 133
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00096
      Location:266 → 323
      Ig; Immunoglobulin domain
      pfam13499
      Location:182 → 243
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      75981582..76617317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501262.1 → XP_006501325.1  follistatin-related protein 5 isoform X3

      UniProtKB/TrEMBL
      Q3UUI4
      Conserved Domains (4) summary
      cd05736
      Location:358 → 433
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
      cd00104
      Location:93 → 133
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00096
      Location:266 → 323
      Ig; Immunoglobulin domain
      pfam13499
      Location:182 → 243
      EF-hand_7; EF-hand domain pair

    2. XM_017319517.1 → XP_017175006.1  follistatin-related protein 5 isoform X2

      UniProtKB/TrEMBL
      Q3UUI4
      Conserved Domains (5) summary
      cd00104
      Location:92 → 132
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam13499
      Location:181 → 242
      EF-hand_7; EF-hand domain pair
      pfam13927
      Location:255 → 322
      Ig_3; Immunoglobulin domain
      cd00096
      Location:265 → 269
      Ig; Ig strand B [structural motif]
      cd05736
      Location:340 → 432
      IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

    3. XM_006501263.1 → XP_006501326.1  follistatin-related protein 5 isoform X4

      UniProtKB/TrEMBL
      Q3UUI4
      Conserved Domains (4) summary
      cd05736
      Location:357 → 432
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
      cd00104
      Location:92 → 132
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00096
      Location:265 → 322
      Ig; Immunoglobulin domain
      pfam13499
      Location:181 → 242
      EF-hand_7; EF-hand domain pair

    4. XM_030252533.2 → XP_030108393.1  follistatin-related protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q80TG3, Q8BFR2, Q8C4T3
      UniProtKB/TrEMBL
      Q3UUI4
      Conserved Domains (4) summary
      cd05736
      Location:358 → 433
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
      cd00104
      Location:93 → 133
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd00096
      Location:266 → 323
      Ig; Immunoglobulin domain
      pfam13499
      Location:182 → 243
      EF-hand_7; EF-hand domain pair

    5. XM_036162997.1 → XP_036018890.1  follistatin-related protein 5 isoform X2

      UniProtKB/TrEMBL
      Q3UUI4
      Conserved Domains (5) summary
      cd00104
      Location:92 → 132
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam13499
      Location:181 → 242
      EF-hand_7; EF-hand domain pair
      pfam13927
      Location:255 → 322
      Ig_3; Immunoglobulin domain
      cd00096
      Location:265 → 269
      Ig; Ig strand B [structural motif]
      cd05736
      Location:340 → 432
      IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFR2.1 GenPept UniProtKB/Swiss-Prot:Q8BFR2

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