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    Ppa2 pyrophosphatase (inorganic) 2 [ Mus musculus (house mouse) ]

    Gene ID: 74776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppa2provided by MGI
    Official Full Name
    pyrophosphatase (inorganic) 2provided by MGI
    Primary source
    MGI:MGI:1922026
    See related
    Ensembl:ENSMUSG00000028013 AllianceGenome:MGI:1922026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sid6306; 1110013G13Rik
    Summary
    Enables protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Located in mitochondrion. Is active in synapse. Orthologous to human PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 80.8), kidney adult (RPKM 69.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppa2 in Genome Data Viewer
    Location:
    3 G3; 3 61.71 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (133015842..133083996)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133310059..133378235)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene integrator complex subunit 12 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene STARR-seq mESC enhancer starr_09025 Neighboring gene STARR-seq mESC enhancer starr_09033 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_09034 Neighboring gene STARR-positive B cell enhancer ABC_E6131 Neighboring gene STARR-seq mESC enhancer starr_09035 Neighboring gene predicted gene 49316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Qi Z, et al. Neurochem Int, 2011 Oct. PMID 21672589
    2. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. Xing Y, et al. J Exp Med, 2005 Sep 5. PMID 16129705, Free PMC Article
    3. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, et al. Hum Mol Genet, 2016 Apr 1. PMID 26792178, Free PMC Article
    4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    5. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. downregulation of protein phosphatase 2 activity in PINK1-silenced cells promotes the protective effect of autophagy through phosphorylation of Bcl-2
      Title: Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC6539

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inorganic diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diphosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphate-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inorganic pyrophosphatase 2, mitochondrial
    Names
    PPase 2
    pyrophosphate phospho-hydrolase 2
    NP_001280570.1
    NP_666253.1
    XP_006502279.1
    XP_006502280.1
    XP_030108717.1
    XP_030108718.1
    XP_036019259.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293641.1 → NP_001280570.1  inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA444705, AC125040, AK090384
      Consensus CDS
      CCDS80024.1
      UniProtKB/TrEMBL
      D3Z636
      Related
      ENSMUSP00000113369.2, ENSMUST00000122334.8
      Conserved Domains (1) summary
      cl00217
      Location:3 → 284
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    2. NM_146141.2 → NP_666253.1  inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_666253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA444705, AK090384, AK143475
      Consensus CDS
      CCDS17850.1
      UniProtKB/Swiss-Prot
      Q3UPK3, Q8BTG5, Q91VM9, Q9D1E3
      Related
      ENSMUSP00000029644.10, ENSMUST00000029644.16
      Conserved Domains (1) summary
      cl00217
      Location:3 → 284
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      133015842..133083996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163366.1 → XP_036019259.1  inorganic pyrophosphatase 2, mitochondrial isoform X1

    2. XM_006502216.5 → XP_006502279.1  inorganic pyrophosphatase 2, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00217
      Location:3 → 226
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    3. XM_030252857.2 → XP_030108717.1  inorganic pyrophosphatase 2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00217
      Location:3 → 226
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    4. XM_006502217.5 → XP_006502280.1  inorganic pyrophosphatase 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00217
      Location:26 → 167
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    5. XM_030252858.2 → XP_030108718.1  inorganic pyrophosphatase 2, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl00217
      Location:26 → 167
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VM9.1 GenPept UniProtKB/Swiss-Prot:Q91VM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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