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    Gclm glutamate cysteine ligase, modifier subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29739, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gclmprovided by RGD
    Official Full Name
    glutamate cysteine ligase, modifier subunitprovided by RGD
    Primary source
    RGD:619871
    See related
    EnsemblRapid:ENSRNOG00000013409 AllianceGenome:RGD:619871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glclr
    Summary
    Enables glutamate-cysteine ligase activity and glutamate-cysteine ligase catalytic subunit binding activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to hepatocyte growth factor stimulus; and cellular response to thyroxine stimulus. Part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 2962.3), Liver (RPKM 419.8) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Gclm in Genome Data Viewer
    Location:
    2q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (213032135..213052192)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (210347482..210367537)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (225827504..225847876)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 4 Neighboring gene uncharacterized LOC102555028 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 2 Neighboring gene transfer RNA arginine (anticodon UCU) 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel diameter maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel diameter maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hepatocyte growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to thyroxine stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatic stellate cell activation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glutamate-cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of glutamate-cysteine ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to human chorionic gonadotropin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nitrosative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of glutamate-cysteine ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of glutamate-cysteine ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate--cysteine ligase regulatory subunit
    Names
    GCS light chain
    gamma-ECS regulatory subunit
    gamma-glutamylcysteine synthetase regulatory subunit
    glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
    NP_059001.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017305.2NP_059001.1  glutamate--cysteine ligase regulatory subunit

      See identical proteins and their annotated locations for NP_059001.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078867
      UniProtKB/Swiss-Prot
      P48508
      UniProtKB/TrEMBL
      A6HVF9, Q2VC85
      Related
      ENSRNOP00000018343.3, ENSRNOT00000018343.6
      Conserved Domains (1) summary
      cl00470
      Location:86211
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      213032135..213052192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)