Atp5f1c ATP synthase F1 subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp5f1cprovided by RGD
Official Full Name: ATP synthase F1 subunit gammaprovided by RGD
Primary source: RGD:620011
See related: EnsemblRapid:ENSRNOG00000019223 AllianceGenome:RGD:620011
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atp5c1
Summary: Contributes to ATP hydrolysis activity. Involved in cellular response to nitric oxide. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex, catalytic core F(1). Biomarker of schizophrenia. Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 5362.9), Muscle (RPKM 3755.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (73333584..73355872)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (68423927..68446169)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (72209321..72231562)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_5003-5004:996690032:1 (e-PCR)
- UniSTS:269433

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of proton-transporting ATP synthase complex	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit gamma, mitochondrial

Names: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; F-ATPase gamma subunit

NP_446277.1

EC 3.6.1.14

XP_006254291.1

EC 3.6.1.14

XP_006254292.1

EC 3.6.1.14

XP_006254293.1

EC 3.6.1.14

XP_063132091.1

EC 3.6.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053825.2 → NP_446277.1 ATP synthase subunit gamma, mitochondrial

See identical proteins and their annotated locations for NP_446277.1

Status: PROVISIONAL

Source sequence(s)

BC059158

UniProtKB/TrEMBL

A0A8I5YBP6, F7FFJ9, Q6PCU0

Conserved Domains (1) summary

TIGR01146
Location:26 → 297

ATPsyn_F1gamma; ATP synthase, F1 gamma subunit