Mat2a methionine adenosyltransferase 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mat2aprovided by RGD
Official Full Name: methionine adenosyltransferase 2Aprovided by RGD
Primary source: RGD:619985
See related: EnsemblRapid:ENSRNOG00000013520 AllianceGenome:RGD:619985
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sams2
Summary: Enables ATP binding activity; amino acid binding activity; and methionine adenosyltransferase activity. Involved in several processes, including S-adenosylmethionine biosynthetic process; circadian rhythm; and response to cAMP. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 1472.6), Thymus (RPKM 548.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106048043..106053612, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104489877..104495447, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100297478..100303047, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis.
Title: Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis.
MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage via MAT2A-mediated the p38 MAPK/STAT3 signaling pathway.
Title: MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage via MAT2A-mediated the p38 MAPK/STAT3 signaling pathway.
CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation.
Title: CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation.
we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma.
Title: Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
PPARgamma as a negative regulator of MAT2A in quiescent hepatic stellate cells. A switch from quiescence to activation abolishes this control and allows PPARbeta to up-regulate MAT2A transcription.
Title: Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells.
Data support a role for AUF1 and HuR/methyl-HuR in liver de-differentiation and development through the posttranslational regulation of MAT1A and MAT2A mRNAs.
Title: HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Expression of Mat2a was decreased by treatment with the protective agent from Aspergillus.
Title: A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats.
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.
Title: Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.
Results show that the molecular mechanism of MAT2A expression is different during G0-G1 or G1-S transition and this may be related to the distinct requirements of S-adenosylmethionine during liver regeneration.
Title: Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methionine adenosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to methionine	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of methionine adenosyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of methionine adenosyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of methionine adenosyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: S-adenosylmethionine synthase isoform type-2

Names: MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; non-hepatic-type S-adenosylmethionine synthetase

NP_599178.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134351.1 → NP_599178.1 S-adenosylmethionine synthase isoform type-2

See identical proteins and their annotated locations for NP_599178.1

Status: PROVISIONAL

Source sequence(s)

J05571

UniProtKB/Swiss-Prot

P18298

UniProtKB/TrEMBL

A0A8I6ALA1, A6IAC2

Related

ENSRNOP00000094572.1, ENSRNOT00000098451.2

Conserved Domains (4) summary

PTZ00104
Location:16 → 395

PTZ00104; S-adenosylmethionine synthase; Provisional

pfam00438
Location:17 → 114

S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

pfam02772
Location:129 → 250

S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain

pfam02773
Location:252 → 388

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain