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    Trappc2 trafficking protein particle complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501550, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Trappc2provided by RGD
    Official Full Name
    trafficking protein particle complex subunit 2provided by RGD
    Primary source
    RGD:1306925
    See related
    EnsemblRapid:ENSRNOG00000042276 AllianceGenome:RGD:1306925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306925
    Summary
    Predicted to enable transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of gene expression; and skeletal system development. Predicted to be located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to several human genes including TRAPPC2 (trafficking protein particle complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 226.5), Lung (RPKM 101.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trappc2 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (31617107..31647035, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (28004051..28015336, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (29550871..29562135, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene stabilizer of axonemal microtubules like 1 Neighboring gene RAB9A, member RAS oncogene family Neighboring gene Ofd1 centriole and centriolar satellite protein Neighboring gene glycoprotein m6b Neighboring gene gem (nuclear organelle) associated protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda. Gedeon AK, et al. Nat Genet, 1999 Aug. PMID 10431248
    2. Interaction of Sedlin with chloride intracellular channel proteins. Fan L, et al. FEBS Lett, 2003 Apr 10. PMID 12681486
    3. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. Ghosh AK, et al. Mol Cell Biol, 2001 Jan. PMID 11134351, Free PMC Article
    4. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. Milev MP, et al. J Cell Biol, 2015 Apr 27. PMID 25918224, Free PMC Article
    5. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109621

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 2
    Names
    sedlin
    trafficking protein particle complex 2
    trafficking protein particle complex protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024965.1 → NP_001020136.1  trafficking protein particle complex subunit 2

      See identical proteins and their annotated locations for NP_001020136.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091429
      UniProtKB/TrEMBL
      A6K2H9, A6K2I0, Q5BJL8
      Related
      ENSRNOP00000062350.1, ENSRNOT00000068113.3
      Conserved Domains (1) summary
      cd14825
      Location:4 → 138
      TRAPPC2_sedlin; Trafficking protein particle complex subunit 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      31617107..31647035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280240.1 → XP_063136310.1  trafficking protein particle complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A6K2H9, A6K2I0, Q5BJL8

    2. XM_063280241.1 → XP_063136311.1  trafficking protein particle complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A6K2H9, A6K2I0, Q5BJL8

    RNA

    1. XR_010061223.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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