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    Med23 mediator complex subunit 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309565, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Med23provided by RGD
    Official Full Name
    mediator complex subunit 23provided by RGD
    Primary source
    RGD:1307671
    See related
    EnsemblRapid:ENSRNOG00000013422 AllianceGenome:RGD:1307671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crsp3
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 144.5), Lung (RPKM 115.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med23 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (22309613..22377745, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (20490315..20558461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (21539765..21587675, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene arginase 1 Neighboring gene uncharacterized LOC120098836 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene uncharacterized LOC102553363 Neighboring gene uncharacterized LOC134484968

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. Kasper LH, et al. PLoS One, 2014. PMID 25054639, Free PMC Article
    2. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Ryu S, et al. Nature, 1999 Feb 4. PMID 9989412
    3. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
    4. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of T cell extravasation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 23
    Names
    CRSP complex subunit 3
    cofactor required for Sp1 transcriptional activation subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277054.1 → NP_001263983.1  mediator of RNA polymerase II transcription subunit 23

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5EB59
      UniProtKB/TrEMBL
      A0A0H2UHV2
      Related
      ENSRNOP00000036610.5, ENSRNOT00000032424.7
      Conserved Domains (1) summary
      pfam11573
      Location:4 → 1310
      Med23; Mediator complex subunit 23

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      22309613..22377745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080800.2 → XP_038936728.1  mediator of RNA polymerase II transcription subunit 23 isoform X2

      UniProtKB/Swiss-Prot
      Q5EB59
      Conserved Domains (1) summary
      pfam11573
      Location:4 → 1314
      Med23; Mediator complex subunit 23

    2. XM_008758613.4 → XP_008756835.1  mediator of RNA polymerase II transcription subunit 23 isoform X5

      UniProtKB/Swiss-Prot
      Q5EB59
      Related
      ENSRNOP00000111413.1, ENSRNOT00000158273.1
      Conserved Domains (1) summary
      pfam11573
      Location:4 → 1278
      Med23; Mediator complex subunit 23

    3. XM_063265563.1 → XP_063121633.1  mediator of RNA polymerase II transcription subunit 23 isoform X4

      UniProtKB/Swiss-Prot
      Q5EB59

    4. XM_039080806.2 → XP_038936734.1  mediator of RNA polymerase II transcription subunit 23 isoform X3

      UniProtKB/Swiss-Prot
      Q5EB59
      UniProtKB/TrEMBL
      A0A0H2UHV2
      Conserved Domains (1) summary
      pfam11573
      Location:4 → 1310
      Med23; Mediator complex subunit 23

    5. XM_008758612.4 → XP_008756834.1  mediator of RNA polymerase II transcription subunit 23 isoform X1

      UniProtKB/Swiss-Prot
      Q5EB59
      UniProtKB/TrEMBL
      A0A8I6A9J3
      Conserved Domains (1) summary
      pfam11573
      Location:4 → 1316
      Med23; Mediator complex subunit 23

    6. XM_063265558.1 → XP_063121628.1  mediator of RNA polymerase II transcription subunit 23 isoform X1

      UniProtKB/Swiss-Prot
      Q5EB59
      UniProtKB/TrEMBL
      A0A8I6A9J3
      Related
      ENSRNOP00000090175.1, ENSRNOT00000097341.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EB59.2 GenPept UniProtKB/Swiss-Prot:Q5EB59

    Gene LinkOut

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