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    Rusc1 RUN and SH3 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360417, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rusc1provided by RGD
    Official Full Name
    RUN and SH3 domain containing 1provided by RGD
    Primary source
    RGD:2322139
    See related
    EnsemblRapid:ENSRNOG00000043377 AllianceGenome:RGD:2322139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in several cellular components, including Golgi apparatus; early endosome; and microtubule cytoskeleton. Orthologous to human RUSC1 (RUN and SH3 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 70.6), Kidney (RPKM 34.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rusc1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176785711..176794981, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174487921..174497266, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188394114..188403391, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene death associated protein 3 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene RNA, U6 small nuclear 909 Neighboring gene farnesyl diphosphate synthase Neighboring gene pyruvate kinase L/R Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. Napolitano G, et al. J Cell Physiol, 2009 Aug. PMID 19365808
    2. Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons. MacDonald JI, et al. J Neurochem, 2012 Jun. PMID 22404429
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Potential readthrough

    Included gene: Fdps

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex accessory subunit RUSC1
    Names
    RUN and SH3 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427699.1 → NP_001414628.1  AP-4 complex accessory subunit RUSC1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5Y687
      Related
      ENSRNOP00000076679.1, ENSRNOT00000118716.2

    2. NM_001427700.1 → NP_001414629.1  AP-4 complex accessory subunit RUSC1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6G8L3, A6J6B6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176785711..176794981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials