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    Sec63 SEC63 homolog, protein translocation regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309858, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Sec63provided by RGD
    Official Full Name
    SEC63 homolog, protein translocation regulatorprovided by RGD
    Primary source
    RGD:1304984
    See related
    EnsemblRapid:ENSRNOG00000000314 AllianceGenome:RGD:1304984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein transmembrane transporter activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane and post-translational protein targeting to membrane, translocation. Predicted to act upstream of or within liver development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 134.1), Lung (RPKM 130.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sec63 in Genome Data Viewer
    Location:
    20q13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (47827291..47896248)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (46245101..46314055)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (47494270..47563222)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene osteoclastogenesis associated transmembrane protein 1 Neighboring gene uncharacterized LOC134483933 Neighboring gene G protein nucleolar 3, pseudogene 1 Neighboring gene uncharacterized LOC102550842 Neighboring gene ribosomal protein S15, pseudogene 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in SEC63 cause autosomal dominant polycystic liver disease. Davila S, et al. Nat Genet, 2004 Jun. PMID 15133510
    2. Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. Haßdenteufel S, et al. Cell Rep, 2018 May 1. PMID 29719251, Free PMC Article
    3. A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Fedeles SV, et al. Nat Genet, 2011 Jun 19. PMID 21685914, Free PMC Article
    4. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitrogen cycle metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nitrogen cycle metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    translocation protein SEC63 homolog
    Names
    SEC63-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434629.1 → NP_001421558.1  translocation protein SEC63 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0G2JUJ9, A6K6Y0, D4A2Z6

    2. NM_001434630.1 → NP_001421559.1  translocation protein SEC63 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6K6Y0, D4A2Z6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      47827291..47896248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256570.5 → XP_006256632.1  translocation protein SEC63 homolog isoform X1

      Related
      ENSRNOP00000085126.2, ENSRNOT00000110304.2
      Conserved Domains (3) summary
      smart00611
      Location:209 → 715
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:104 → 162
      DnaJ; DnaJ domain
      pfam14797
      Location:564 → 612
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    2. XM_006256571.5 → XP_006256633.1  translocation protein SEC63 homolog isoform X2

      Conserved Domains (3) summary
      smart00611
      Location:209 → 714
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:104 → 162
      DnaJ; DnaJ domain
      pfam14797
      Location:563 → 611
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107637.1: Suppressed sequence

      Description
      NM_001107637.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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