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    Npat nuclear protein, co-activator of histone transcription [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315666, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Npatprovided by RGD
    Official Full Name
    nuclear protein, co-activator of histone transcriptionprovided by RGD
    Primary source
    RGD:1311947
    See related
    EnsemblRapid:ENSRNOG00000024934 AllianceGenome:RGD:1311947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity and transcription corepressor activity. Predicted to be involved in cell cycle G1/S phase transition and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in Cajal body; Gemini of coiled bodies; and cytoplasm. Predicted to be active in nucleus. Orthologous to human NPAT (nuclear protein, coactivator of histone transcription). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 101.7), Spleen (RPKM 77.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Npat in Genome Data Viewer
    Location:
    8q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (62829141..62867065)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (53932993..53970875)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (58120179..58158052)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 65 Neighboring gene ATM serine/threonine kinase Neighboring gene uncharacterized LOC120094159 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene acetyl-CoA acetyltransferase 1 Neighboring gene uncharacterized LOC120094160 Neighboring gene small nucleolar RNA SNORA61 Neighboring gene cullin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. Medina R, et al. Biochemistry, 2008 Nov 4. PMID 18850719, Free PMC Article
    2. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. Mitra P, et al. J Cell Biochem, 2007 May 1. PMID 17163457
    3. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. Medina R, et al. Cancer Res, 2007 Nov 1. PMID 17974976
    4. HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. Miele A, et al. Mol Cell Biol, 2005 Jul. PMID 15988025, Free PMC Article
    5. Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. Gangwani L. J Biol Chem, 2006 Dec 29. PMID 17068332

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Gemini of coiled bodies ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein NPAT
    Names
    nuclear protein in the AT region
    nuclear protein, ataxia-telangiectasia locus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108147.2 → NP_001101617.1  protein NPAT isoform 2

      See identical proteins and their annotated locations for NP_001101617.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A9M9, A6J4J5
      Related
      ENSRNOP00000047149.6, ENSRNOT00000049076.7
      Conserved Domains (1) summary
      pfam15712
      Location:750 → 1415
      NPAT_C; NPAT C terminus

    2. NM_001434409.1 → NP_001421338.1  protein NPAT isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NM_001434410.1 → NP_001421339.1  protein NPAT isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    4. NM_001434411.1 → NP_001421340.1  protein NPAT isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001434412.1 → NP_001421341.1  protein NPAT isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    6. NM_001434413.1 → NP_001421342.1  protein NPAT isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      62829141..62867065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766268.4 → XP_008764490.2  protein NPAT isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9M9, D4A6Y1

    2. XM_063265465.1 → XP_063121535.1  protein NPAT isoform X2

      Related
      ENSRNOP00000073993.3, ENSRNOT00000090114.3

    3. XM_063265466.1 → XP_063121536.1  protein NPAT isoform X3

    4. XM_039081460.2 → XP_038937388.1  protein NPAT isoform X5

      Conserved Domains (2) summary
      smart00667
      Location:3 → 32
      LisH; Lissencephaly type-1-like homology motif
      pfam15712
      Location:379 → 877
      NPAT_C; NPAT C-terminus

    5. XM_063265467.1 → XP_063121537.1  protein NPAT isoform X6

    6. XM_008766266.4 → XP_008764488.2  protein NPAT isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9M9
      Conserved Domains (1) summary
      pfam15712
      Location:681 → 1348
      NPAT_C; NPAT C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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