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    Cacybp calcyclin binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289144, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cacybpprovided by RGD
    Official Full Name
    calcyclin binding proteinprovided by RGD
    Primary source
    RGD:1303146
    See related
    AllianceGenome:RGD:1303146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including protein domain specific binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to calcium ion; positive regulation of DNA replication; and response to growth hormone. Located in cell body. Biomarker of myocardial infarction. Orthologous to human CACYBP (calcyclin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 412.4), Brain (RPKM 390.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cacybp in Genome Data Viewer
    Location:
    13q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (74970917..74981298, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (72437485..72447810, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (77948771..77959089, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096295 Neighboring gene tenascin N Neighboring gene uncharacterized LOC134481579 Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene RAB GTPase activating protein 1-like Neighboring gene small nucleolar RNA SNORA67

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC93921

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S100 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004208.1NP_001004208.1  calcyclin-binding protein

      See identical proteins and their annotated locations for NP_001004208.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079007
      UniProtKB/Swiss-Prot
      Q6AYK6
      UniProtKB/TrEMBL
      A0A096MJT0, A6ID58
      Conserved Domains (3) summary
      cd06468
      Location:76168
      p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
      pfam05002
      Location:183218
      SGS; SGS domain
      pfam09032
      Location:576
      Siah-Interact_N; Siah interacting protein, N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      74970917..74981298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598707.2XP_017454196.1  calcyclin-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A096MJT0, A6ID59
      Conserved Domains (3) summary
      cd06468
      Location:31123
      p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
      pfam05002
      Location:138173
      SGS; SGS domain
      pfam09032
      Location:131
      Siah-Interact_N; Siah interacting protein, N terminal