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    Fer1l4 fer-1 like family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 74562, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fer1l4provided by MGI
    Official Full Name
    fer-1 like family member 4provided by MGI
    Primary source
    MGI:MGI:1921812
    See related
    Ensembl:ENSMUSG00000013338 AllianceGenome:MGI:1921812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130402C12Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in plasma membrane organization. Predicted to be located in membrane. Is expressed in lower urinary tract and testis. Orthologous to human FER1L4 (fer-1 like family member 4 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 23.1), stomach adult (RPKM 19.3) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See Fer1l4 in Genome Data Viewer
    Location:
    2 H1; 2 77.32 cM
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155861059..155894939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156019139..156053019, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene centrosomal protein 250 Neighboring gene predicted gene, 50621 Neighboring gene RIKEN cDNA 6430550D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9074 Neighboring gene ERGIC and golgi 3 Neighboring gene AE binding protein 2 pseudogene Neighboring gene predicted gene, 39970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Morohoshi A, et al. Sci Adv, 2023 Jan 25. PMID 36696506, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fer-1-like protein 4
    Names
    fer-1-like 4
    otoferlin-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136556.2 → NP_001130028.1  fer-1-like protein 4

      Status: VALIDATED

      Source sequence(s)
      AL833786
      UniProtKB/Swiss-Prot
      A3KGK3, B7ZCP2
      UniProtKB/TrEMBL
      Z4YL23
      Related
      ENSMUSP00000105240.2, ENSMUST00000109611.8
      Conserved Domains (9) summary
      cd04011
      Location:225 → 335
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:967 → 1101
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:391 → 540
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1449 → 1572
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 129
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1692 → 1825
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:862 → 931
      FerB; FerB (NUC096) domain
      pfam08151
      Location:333 → 383
      FerI; FerI (NUC094) domain
      pfam16165
      Location:1834 → 1985
      Ferlin_C; Ferlin C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155861059..155894939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500307.1 → XP_006500370.1  fer-1-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      A3KGK3, B7ZCP2
      Conserved Domains (9) summary
      cd04011
      Location:225 → 335
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:967 → 1101
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:391 → 540
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1449 → 1572
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 129
      C2A_Ferlin; C2 domain first repeat in Ferlin
      cd08374
      Location:1692 → 1825
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:862 → 931
      FerB; FerB (NUC096) domain
      pfam08151
      Location:333 → 383
      FerI; FerI (NUC094) domain
      pfam16165
      Location:1834 → 1940
      Ferlin_C; Ferlin C-terminus

    2. XM_006500309.4 → XP_006500372.1  fer-1-like protein 4 isoform X3

      Related
      ENSMUST00000150538.8
      Conserved Domains (5) summary
      cd04017
      Location:96 → 230
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:578 → 701
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:821 → 954
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:1 → 60
      FerB; FerB (NUC096) domain
      pfam16165
      Location:963 → 1116
      Ferlin_C; Ferlin C-terminus

    3. XM_006500308.2 → XP_006500371.1  fer-1-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      A3KGK3, B7ZCP2
      Conserved Domains (7) summary
      cd04011
      Location:225 → 335
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:967 → 1101
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:391 → 540
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1449 → 1572
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08373
      Location:3 → 129
      C2A_Ferlin; C2 domain first repeat in Ferlin
      pfam08150
      Location:862 → 931
      FerB; FerB (NUC096) domain
      pfam08151
      Location:333 → 383
      FerI; FerI (NUC094) domain

    RNA

    1. XR_003953731.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KGK3.3 GenPept UniProtKB/Swiss-Prot:A3KGK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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