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    Dgkh diacylglycerol kinase, eta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dgkhprovided by RGD
    Official Full Name
    diacylglycerol kinase, etaprovided by RGD
    Primary source
    RGD:1561955
    See related
    EnsemblRapid:ENSRNOG00000010065 AllianceGenome:RGD:1561955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561955
    Summary
    Predicted to enable several functions, including ATP-dependent diacylglycerol kinase activity; SAM domain binding activity; and identical protein binding activity. Predicted to be involved in glycerolipid metabolic process; lipid phosphorylation; and phospholipase C/protein kinase C signal transduction. Predicted to be located in actin cytoskeleton and endosome. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human DGKH (diacylglycerol kinase eta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 108.2), Brain (RPKM 78.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dgkh in Genome Data Viewer
    Location:
    15q11
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (60390279..60559777, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (53981079..54150470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (60791574..60967236, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549816 Neighboring gene uncharacterized LOC120097049 Neighboring gene A-kinase anchoring protein 11 Neighboring gene uncharacterized LOC108353040 Neighboring gene uncharacterized LOC120097120 Neighboring gene von Willebrand factor A domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of two splice variants of human diacylglycerol kinase eta. Murakami T, et al. J Biol Chem, 2003 Sep 5. PMID 12810723
    2. Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method. Sato M, et al. Pharmacology, 2013. PMID 23949095
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SAM domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C/protein kinase C signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase eta
    XP_006252425.1
    XP_008769142.1
    XP_038949963.2
    XP_038949964.2
    XP_038949966.1
    XP_063130509.1
    XP_063130510.1
    XP_063130511.1
    XP_063130512.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427603.2 → NP_001414532.2  diacylglycerol kinase eta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZJG9
      Related
      ENSRNOP00000077411.2, ENSRNOT00000097320.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      60390279..60559777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094036.2 → XP_038949964.2  diacylglycerol kinase eta isoform X2

      UniProtKB/TrEMBL
      D3ZSZ6
      Related
      ENSRNOP00000054887.5, ENSRNOT00000058079.6

    2. XM_063274439.1 → XP_063130509.1  diacylglycerol kinase eta isoform X3

      UniProtKB/TrEMBL
      A0A8I6A873

    3. XM_039094035.2 → XP_038949963.2  diacylglycerol kinase eta isoform X1

      UniProtKB/TrEMBL
      D3ZSZ6

    4. XM_008770920.4 → XP_008769142.1  diacylglycerol kinase eta isoform X4

      See identical proteins and their annotated locations for XP_008769142.1

      UniProtKB/TrEMBL
      D3ZSZ6
      Conserved Domains (5) summary
      cd09576
      Location:1005 → 1069
      SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
      smart00045
      Location:628 → 785
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:198 → 320
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20848
      Location:11 → 96
      C1_DGKeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
      cd20894
      Location:107 → 168
      C1_DGKeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins

    5. XM_006252363.5 → XP_006252425.1  diacylglycerol kinase eta isoform X4

      See identical proteins and their annotated locations for XP_006252425.1

      UniProtKB/TrEMBL
      D3ZSZ6
      Conserved Domains (5) summary
      cd09576
      Location:1005 → 1069
      SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
      smart00045
      Location:628 → 785
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:198 → 320
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20848
      Location:11 → 96
      C1_DGKeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
      cd20894
      Location:107 → 168
      C1_DGKeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins

    6. XM_039094038.2 → XP_038949966.1  diacylglycerol kinase eta isoform X4

      UniProtKB/TrEMBL
      D3ZSZ6
      Conserved Domains (5) summary
      cd09576
      Location:1005 → 1069
      SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
      smart00045
      Location:628 → 785
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:198 → 320
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20848
      Location:11 → 96
      C1_DGKeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
      cd20894
      Location:107 → 168
      C1_DGKeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins

    7. XM_063274440.1 → XP_063130510.1  diacylglycerol kinase eta isoform X4

      UniProtKB/TrEMBL
      D3ZSZ6

    8. XM_063274441.1 → XP_063130511.1  diacylglycerol kinase eta isoform X4

      UniProtKB/TrEMBL
      D3ZSZ6

    9. XM_063274442.1 → XP_063130512.1  diacylglycerol kinase eta isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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