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    NIP7 ribosome biosynthesis protein NIP7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855890, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NIP7
    Official Full Name
    ribosome biosynthesis protein NIP7
    Primary source
    SGD:S000006132
    Locus tag
    YPL211W
    See related
    AllianceGenome:SGD:S000006132; FungiDB:YPL211W; VEuPathDB:YPL211W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in assembly of large subunit precursor of preribosome and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleus. Part of preribosome, large subunit precursor. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NIP7 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (153495..154040)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit LEA1 Neighboring gene pseudouridine synthase PUS1 Neighboring gene signal recognition particle subunit SRP72 Neighboring gene aurora kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis. Zanchin NI, et al. Mol Cell Biol, 1997 Sep. PMID 9271378, Free PMC Article
    2. Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA. Coltri PP, et al. Biochemistry, 2007 Dec 11. PMID 18001138
    3. Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Zanchin NI, et al. Mol Cell Biol, 1999 Feb. PMID 9891085, Free PMC Article
    4. Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. Granato DC, et al. FEBS J, 2005 Sep. PMID 16128814
    5. The essential nucleolar yeast protein Nop8p controls the exosome function during 60S ribosomal subunit maturation. Santos MC, et al. PLoS One, 2011. PMID 21747919, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in assembly of large subunit precursor of preribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome biosynthesis protein NIP7
    NP_015113.1
    • Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      153495..154040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184025.1 → NP_015113.1  TPA: ribosome biosynthesis protein NIP7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3F9, Q08962
      UniProtKB/TrEMBL
      A6ZW44, B3LKL9, B5VSW9, C7GN38, C8ZIG8, G2WNX4, N1NXY7
      Conserved Domains (1) summary
      COG1374
      Location:1 → 177
      NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08962.1

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