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    Dmrt3 doublesex and mab-3 related transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293976, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dmrt3provided by RGD
    Official Full Name
    doublesex and mab-3 related transcription factor 3provided by RGD
    Primary source
    RGD:1306043
    See related
    EnsemblRapid:ENSRNOG00000016284 AllianceGenome:RGD:1306043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 5.4) and Testes (RPKM 2.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmrt3 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (232670642..232690557)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (223244340..223264254)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (243589607..243602926)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAN, member RAS oncogene family, pseudogene 1 Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene doublesex and mab-3 related transcription factor 2 Neighboring gene transfer RNA proline (anticodon AGG) 60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deletion of ultraconserved elements yields viable mice. Ahituv N, et al. PLoS Biol, 2007 Sep. PMID 17803355, Free PMC Article
    2. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA. Murphy MW, et al. BMC Mol Biol, 2007 Jul 2. PMID 17605809, Free PMC Article
    3. Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. Andersson LS, et al. Nature, 2012 Aug 30. PMID 22932389, Free PMC Article
    4. The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. Konno D, et al. PLoS One, 2012. PMID 23056351, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within male sex differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventral spinal cord interneuron specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    doublesex and mab-3 related transcription factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106358.1 → NP_001099828.1  doublesex and mab-3 related transcription factor 3

      See identical proteins and their annotated locations for NP_001099828.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/Swiss-Prot
      D4A218
      Related
      ENSRNOP00000021792.5, ENSRNOT00000021792.7
      Conserved Domains (2) summary
      cd14419
      Location:253 → 295
      CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)
      pfam00751
      Location:25 → 71
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      232670642..232690557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108987.2 → XP_038964915.1  doublesex and mab-3 related transcription factor 3 isoform X1

      UniProtKB/Swiss-Prot
      D4A218
      Conserved Domains (2) summary
      cd14419
      Location:253 → 295
      CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)
      pfam00751
      Location:25 → 71
      DM; DM DNA binding domain

    2. XM_063287107.1 → XP_063143177.1  doublesex and mab-3 related transcription factor 3 isoform X1

      UniProtKB/Swiss-Prot
      D4A218
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A218.1 GenPept UniProtKB/Swiss-Prot:D4A218

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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