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    Neil2 nei-like DNA glycosylase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neil2provided by RGD
    Official Full Name
    nei-like DNA glycosylase 2provided by RGD
    Primary source
    RGD:1312033
    See related
    EnsemblRapid:ENSRNOG00000010696 AllianceGenome:RGD:1312033
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm; mitotic spindle; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NEIL2 (nei like DNA glycosylase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 12.6), Kidney (RPKM 8.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neil2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41620650..41631551, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37444676..37454863, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46371780..46382730, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cathepsin B Neighboring gene uncharacterized LOC134482130 Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC102548615 Neighboring gene uncharacterized LOC120097012

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity. Ma H, et al. Toxicol Appl Pharmacol, 2011 Feb 15. PMID 21145906, Free PMC Article
    2. The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. Conlon KA, et al. DNA Repair (Amst), 2005 Apr 4. PMID 15725623
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the spleen aniline-induced oxidative stress is associated with an induction of NEIL1/2.
      Title: Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 8-like 2
    Names
    endonuclease VIII-like 2
    NP_001100740.1
    XP_017455183.2
    XP_063130354.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107270.1 → NP_001100740.1  endonuclease 8-like 2

      See identical proteins and their annotated locations for NP_001100740.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474023
      UniProtKB/TrEMBL
      A6K6F8, D4ABX3
      Related
      ENSRNOP00000014198.4, ENSRNOT00000014198.6
      Conserved Domains (2) summary
      cd08968
      Location:1 → 182
      MeNeil2_N; N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2)
      COG0266
      Location:152 → 317
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      41620650..41631551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274284.1 → XP_063130354.1  endonuclease 8-like 2 isoform X2

      UniProtKB/TrEMBL
      A6K6F8, D4ABX3

    2. XM_017599694.3 → XP_017455183.2  endonuclease 8-like 2 isoform X1

      Conserved Domains (2) summary
      COG0266
      Location:216 → 381
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      cl03119
      Location:110 → 246
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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