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    Ap4e1 adaptor related protein complex 4 subunit epsilon 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap4e1provided by RGD
    Official Full Name
    adaptor related protein complex 4 subunit epsilon 1provided by RGD
    Primary source
    RGD:1562199
    See related
    EnsemblRapid:ENSRNOG00000022938 AllianceGenome:RGD:1562199
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562199
    Summary
    Predicted to enable cargo adaptor activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be part of AP-4 adaptor complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 51 and stuttering. Orthologous to human AP4E1 (adaptor related protein complex 4 subunit epsilon 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 72.7), Kidney (RPKM 65.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap4e1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134726338..134792820)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114272997..114339484)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119484714..119548491)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene signal peptide peptidase-like 2A Neighboring gene uncharacterized LOC134486145 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene uncharacterized LOC134486146 Neighboring gene biliverdin reductase A Neighboring gene non-SMC condensin I complex, subunit H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AP-4, a novel protein complex related to clathrin adaptors. Dell'Angelica EC, et al. J Biol Chem, 1999 Mar 12. PMID 10066790
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cargo adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-4 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-4 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex subunit epsilon-1
    Names
    adaptor-related protein complex 4, epsilon 1 subunit
    adaptor-related protein complex AP-4, epsilon 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191742.1 → NP_001178671.1  AP-4 complex subunit epsilon-1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZX21
      Related
      ENSRNOP00000112697.1, ENSRNOT00000164402.1
      Conserved Domains (2) summary
      pfam01602
      Location:51 → 595
      Adaptin_N; Adaptin N terminal region
      pfam14807
      Location:1026 → 1125
      AP4E_app_platf; Adaptin AP4 complex epsilon appendage platform

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134726338..134792820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283751.1 → XP_063139821.1  AP-4 complex subunit epsilon-1 isoform X1

    2. XM_039104990.2 → XP_038960918.1  AP-4 complex subunit epsilon-1 isoform X2

      Conserved Domains (2) summary
      pfam01602
      Location:2 → 205
      Adaptin_N; Adaptin N terminal region
      pfam14807
      Location:639 → 739
      AP4E_app_platf; Adaptin AP4 complex epsilon appendage platform

    3. XM_063283752.1 → XP_063139822.1  AP-4 complex subunit epsilon-1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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