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    St6galnac3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St6galnac3provided by RGD
    Official Full Name
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3provided by RGD
    Primary source
    RGD:3677
    See related
    EnsemblRapid:ENSRNOG00000056894 AllianceGenome:RGD:3677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat7c
    Summary
    Enables sialyltransferase activity. Predicted to be involved in ceramide metabolic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Predicted to be located in nucleoplasm. Orthologous to human ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 250.7), Brain (RPKM 72.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St6galnac3 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (244789627..245304975, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242129755..242645120, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (259379653..259918813, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene uncharacterized LOC134485772 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC103691740 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a developmentally regulated N-acetylgalactosamine alpha2,6-sialyltransferase specific for sialylated glycoconjugates. Sjoberg ER, et al. J Biol Chem, 1996 Mar 29. PMID 8631773
    2. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Senda M, et al. Biochem J, 2007 Mar 15. PMID 17123352, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosylceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Names
    ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
    SIAT7-C
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    ST6 GalNAc alpha-2,6-sialyltransferase 3
    ST6GalNAc III
    ST6GalNAcIII
    STY
    galNAc alpha-2,6-sialyltransferase III
    sialyltransferase 7 ((alpha-N-acetylneuraminyl 23-betagalactosyl-13)-N-acetyl galactosaminide alpha-26-sialyltransferase) C
    sialyltransferase 7c
    NP_061996.2
    XP_038958059.1
    XP_038958060.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019123.2 → NP_061996.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A096MK04, A6HWN0, Q6IN13
      Related
      ENSRNOP00000073209.1, ENSRNOT00000082253.3
      Conserved Domains (1) summary
      pfam00777
      Location:77 → 297
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      244789627..245304975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102131.2 → XP_038958059.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:12 → 232
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_039102132.2 → XP_038958060.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:77 → 135
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64686.1 GenPept UniProtKB/Swiss-Prot:Q64686

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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