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Anxa1 annexin A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25380, updated on 9-Dec-2024

Summary

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Official Symbol: Anxa1provided by RGD
Official Full Name: annexin A1provided by RGD
Primary source: RGD:2118
See related: EnsemblRapid:ENSRNOG00000017469 AllianceGenome:RGD:2118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p35; Anx1
Summary: Enables several functions, including DNA/DNA annealing activity; double-stranded DNA helicase activity; and phospholipase A2 inhibitor activity. Contributes to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including estrous cycle; hepatocyte differentiation; and peptide hormone secretion. Located in extracellular space; mast cell granule; and mitochondrial membrane. Part of protein-containing complex. Is active in synaptic membrane. Used to study acute kidney failure; brain ischemia; pleurisy; and uveitis. Biomarker of several diseases, including carcinoma (multiple); cerebral infarction; eye disease (multiple); hyperthyroidism; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 1237.6), Uterus (RPKM 775.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Anxa1 in Genome Data Viewer

Location:: 1q51

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (227287713..227306739, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (217861175..217877205, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (237893983..237910002, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Annexin A1 conveys neuroprotective function via inhibiting oxidative stress in diffuse axonal injury of rats.
Title: Annexin A1 conveys neuroprotective function via inhibiting oxidative stress in diffuse axonal injury of rats.
The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats.
Title: The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats.
Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
Title: Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
Title: Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats.
Title: Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats.
2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.
Title: 2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.
ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway.
Title: ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway.
microRNA-206 overexpression inhibits epithelial-mesenchymal transition and glomerulosclerosis in rats with chronic kidney disease by inhibiting JAK/STAT signaling pathway.
Title: microRNA-206 overexpression inhibits epithelial-mesenchymal transition and glomerulosclerosis in rats with chronic kidney disease by inhibiting JAK/STAT signaling pathway.
silencing of ANXA1 suppressed the apoptosis and inflammatory response of PE rat trophoblasts, and downregulated JAK2/STAK3 pathway.
Title: Silencing of Annexin A1 suppressed the apoptosis and inflammatory response of preeclampsia rat trophoblasts.
ANXA1 is a novel GnRH target gene in gonadotropes. ANXA1 also may be a target of local GnRH in peripheral tissues and may have a different role than that of ANXA5
Title: Annexin A1 is a novel target gene of gonadotropin-releasing hormone in LβT2 gonadotrope cells.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127656 (e-PCR)
- UniSTS:210966

RH94593 (e-PCR)
- UniSTS:119841

RH129631 (e-PCR)
- UniSTS:212928

D1Bda58 (e-PCR)
- UniSTS:239811

RH143668 (e-PCR)
- UniSTS:232914

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA/DNA annealing activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in gliogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in granulocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in granulocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast migration involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
involved_in myoblast migration involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 2 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil clearance	IEA Inferred from Electronic Annotation more info
involved_in neutrophil clearance	ISO Inferred from Sequence Orthology more info
involved_in neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 1 cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in prolactin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostate gland development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info
involved_in regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mast cell granule	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A1

Names: Annexin 1 (p35) (Lipocortin 1); annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; phospholipase A2 inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012904.2 → NP_037036.1 annexin A1

See identical proteins and their annotated locations for NP_037036.1

Status: PROVISIONAL

Source sequence(s)

Y00446

UniProtKB/Swiss-Prot

P07150, Q64664

UniProtKB/TrEMBL

A0A8I6GKK9, A6I0K9

Related

ENSRNOP00000078049.2, ENSRNOT00000116454.2

Conserved Domains (1) summary

pfam00191
Location:118 → 183

Annexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

227287713..227306739 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281726.1 → XP_063137796.1 annexin A1 isoform X1

UniProtKB/Swiss-Prot

P07150, Q64664

UniProtKB/TrEMBL

A0A8I6GKK9, A6I0K9
XM_039101605.1 → XP_038957533.1 annexin A1 isoform X1

UniProtKB/Swiss-Prot

P07150, Q64664

UniProtKB/TrEMBL

A0A8I6GKK9, A6I0K9

Conserved Domains (1) summary

pfam00191
Location:118 → 183

Annexin