Ak3 adenylate kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ak3provided by RGD
Official Full Name: adenylate kinase 3provided by RGD
Primary source: RGD:619885
See related: EnsemblRapid:ENSRNOG00000052506 AllianceGenome:RGD:619885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables adenylate kinase activity and identical protein binding activity. Involved in several processes, including brain development; liver development; and purine nucleotide metabolic process. Located in mitochondrial matrix. Orthologous to human AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 702.5), Adrenal (RPKM 625.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (236151012..236178689, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (226737472..226764647, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (247144486..247169690, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI236739 (e-PCR)
- UniSTS:250624

RH140143 (e-PCR)
- UniSTS:222222

BF390010 (e-PCR)
- UniSTS:249359

RH130555 (e-PCR)
- UniSTS:213839

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside triphosphate adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate adenylate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in AMP phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ITP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ITP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in UTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dATP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle organ development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory bulb development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GTP:AMP phosphotransferase AK3, mitochondrial

Names: AK 3; GTP:AMP phosphotransferase, mitochondrial; adenylate kinase 3 alpha-like 1; adenylate kinase isozyme 3

NP_037350.2

EC 2.7.4.10

XP_063138655.1

EC 2.7.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013218.4 → NP_037350.2 GTP:AMP phosphotransferase AK3, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P29411

UniProtKB/TrEMBL

A0A8I6G902, Q6P2A5

Related

ENSRNOP00000082113.1, ENSRNOT00000114897.2

Conserved Domains (1) summary

pfam00406
Location:12 → 190

ADK; Adenylate kinase