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    Tmc1 transmembrane channel-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmc1provided by RGD
    Official Full Name
    transmembrane channel-like 1provided by RGD
    Primary source
    RGD:1308682
    See related
    EnsemblRapid:ENSRNOG00000051262 AllianceGenome:RGD:1308682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity and voltage-gated calcium channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and vestibular reflex. Predicted to act upstream of or within several processes, including auditory receptor cell development; calcium ion transmembrane transport; and sensory perception of sound. Predicted to be located in external side of plasma membrane and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 5.4), Adrenal (RPKM 2.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmc1 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (227701781..227872534, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (218275249..218446013, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (238336919..238525792, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485210 Neighboring gene aldehyde dehydrogenase family 1, subfamily A7 Neighboring gene uncharacterized LOC102551351 Neighboring gene uncharacterized LOC134485211 Neighboring gene uncharacterized LOC134485212

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Pan B, et al. Neuron, 2013 Aug 7. PMID 23871232, Free PMC Article
    2. Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Kurima K, et al. Nat Genet, 2002 Mar. PMID 11850618
    3. Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. Beurg M, et al. J Gen Physiol, 2014 Jul. PMID 24981230, Free PMC Article
    4. Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. Kawashima Y, et al. J Clin Invest, 2011 Dec. PMID 22105175, Free PMC Article
    5. Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Takayanagi S, et al. Blood, 2006 Jun 1. PMID 16455951

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to mechanosensitive monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vestibular reflex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vestibular reflex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium tip ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 1
    Names
    transmembrane channel-like gene family 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415991.1 → NP_001402920.1  transmembrane channel-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A096MKC4
      Related
      ENSRNOP00000068461.2, ENSRNOT00000076393.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      227701781..227872534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268475.1 → XP_063124545.1  transmembrane channel-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A096MKC4

    2. XM_039084312.2 → XP_038940240.1  transmembrane channel-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A096MKC4
      Conserved Domains (1) summary
      pfam07810
      Location:524 → 639
      TMC; TMC domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108521.1: Suppressed sequence

      Description
      NM_001108521.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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