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    URK1 uridine kinase URK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    URK1
    Official Full Name
    uridine kinase URK1
    Primary source
    SGD:S000005295
    Locus tag
    YNR012W
    See related
    AllianceGenome:SGD:S000005295; FungiDB:YNR012W; VEuPathDB:YNR012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables uridine kinase activity. Involved in pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See URK1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (647432..648937)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Cse2p Neighboring gene DEAH-box RNA-dependent ATPase PRP2 Neighboring gene Pho91p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The URK1 gene of Saccharomyces cerevisiae encoding uridine kinase. Kern L. Nucleic Acids Res, 1990 Sep 11. PMID 2169608, Free PMC Article
    2. The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Kurtz JE, et al. Curr Genet, 2002 Jun. PMID 12111094
    3. Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase. Mitterbauer R, et al. Appl Environ Microbiol, 2002 Mar. PMID 11872485, Free PMC Article
    4. Enhancement of cloned gene product synthesis via autoselection in recombinant Saccharomyces cerevisiae. Napp SJ, et al. Biotechnol Bioeng, 1993 Apr 5. PMID 18609624
    5. Improved protein synthesis and secretion through medium enrichment in a stable recombinant yeast strain. Wang Z, et al. Biotechnol Bioeng, 1993 Jun 5. PMID 18609652

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine-containing compound salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine-containing compound salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uridine kinase URK1
    NP_014409.1
    • Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      647432..648937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183189.1 → NP_014409.1  TPA: uridine kinase URK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1I7, P27515
      UniProtKB/TrEMBL
      B5VR43, C7GLP3, N1NY55
      Conserved Domains (2) summary
      COG0035
      Location:280 → 501
      Upp; Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]
      TIGR00235
      Location:69 → 260
      udk; uridine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27515.1

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