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    ATG40 Atg40p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG40
    Official Full Name
    Atg40p
    Primary source
    SGD:S000005678
    Locus tag
    YOR152C
    See related
    AllianceGenome:SGD:S000005678; FungiDB:YOR152C; VEuPathDB:YOR152C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in cellular response to nitrogen starvation and reticulophagy. Located in cortical endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG40 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (617518..618288, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL23 Neighboring gene DNA-directed RNA polymerase II core subunit RPB2 Neighboring gene ATP-binding cassette multidrug transporter PDR5 Neighboring gene Slp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atg8-mediated super-assembly of Atg40 induces local ER remodeling in reticulophagy. Mochida K, et al. Autophagy, 2020 Dec. PMID 33043769, Free PMC Article
    2. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Chen S, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915089, Free PMC Article
    3. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Chen S, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32690699, Free PMC Article
    4. Functional analysis of six genes from chromosomes XIV and XV of Saccharomyces cerevisiae reveals YOR145c as an essential gene and YNL059c/ARP5 as a strain-dependent essential gene encoding nuclear proteins. Grava S, et al. Yeast, 2000 Aug. PMID 10923024
    5. Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Mochida K, et al. Nature, 2015 Jun 18. PMID 26040717

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.
      Title: Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nitrogen starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reticulophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg40p
    NP_014795.1
    • Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; acts with COPII subunit Sfb3p; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      617518..618288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183571.1 → NP_014795.1  TPA: Atg40p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014795.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2K9, Q99325
      UniProtKB/TrEMBL
      A6ZNZ6, C7GN72, G2WN24, N1NX13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99325.1

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