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    SEC63 protein-transporting protein SEC63 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC63
    Official Full Name
    protein-transporting protein SEC63
    Primary source
    SGD:S000005780
    Locus tag
    YOR254C
    See related
    AllianceGenome:SGD:S000005780; FungiDB:YOR254C; VEuPathDB:YOR254C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PTL1
    Summary
    Enables protein transmembrane transporter activity. Involved in SRP-dependent cotranslational protein targeting to membrane; cytosol to endoplasmic reticulum transport; and post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum. Part of Sec62/Sec63 complex. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC63 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (805032..807023, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tma16p Neighboring gene peptide alpha-N-acetyltransferase subunit NAT5 Neighboring gene Osw1p Neighboring gene putative zinc metalloprotease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation. Feldheim D, et al. Mol Cell Biol, 1992 Jul. PMID 1620130, Free PMC Article
    2. The Sec63p J-domain is required for ERAD of soluble proteins in yeast. Servas C, et al. PLoS One, 2013. PMID 24324744, Free PMC Article
    3. Endoplasmic reticulum dynamics, inheritance, and cytoskeletal interactions in budding yeast. Fehrenbacher KL, et al. Mol Biol Cell, 2002 Mar. PMID 11907267, Free PMC Article
    4. In vivo and in vitro analysis of ptl1, a yeast ts mutant with a membrane-associated defect in protein translocation. Toyn J, et al. EMBO J, 1988 Dec 20. PMID 3072198, Free PMC Article
    5. An in vitro assay using overexpressed yeast SRP demonstrates that cotranslational translocation is dependent upon the J-domain of Sec63p. Willer M, et al. Biochemistry, 2003 Jun 17. PMID 12795613

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Architecture of the active post-translational Sec translocon.
      Title: Architecture of the active post-translational Sec translocon.
    2. Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
      Title: Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
    3. The N-terminus of Sec63 is important for stability of the SEC complex and Sec63 is required for proper sorting of membrane proteins in vivo
      Title: Proper insertion and topogenesis of membrane proteins in the ER depend on Sec63.
    4. Sec63 tightly associates with Sec61 through interactions in cytosolic, transmembrane, and endoplasmic reticulum -luminal domains, prying open Sec61's lateral gate and translocation pore and thus activating the channel for substrate engagement.
      Title: Structure of the posttranslational Sec protein-translocation channel complex from yeast.
    5. The introduction of Sec63 improves secretory proteins in Pichia pastoris secretion 4-7 times.
      Title: Enhanced secretion of heterologous proteins in Pichia pastoris following overexpression of Saccharomyces cerevisiae chaperone proteins.
    6. the Sec63p BRL domain is required for assembly of functional endoplasmic reticulum translocons
      Title: The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytosol to endoplasmic reticulum transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sec62/Sec63 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-transporting protein SEC63
    NP_014897.1
    • Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      805032..807023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183673.1 → NP_014897.1  TPA: protein-transporting protein SEC63 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2V5, P14906, Q08690
      UniProtKB/TrEMBL
      A6ZP92, B3LJS2, N1NYR9
      Conserved Domains (1) summary
      COG5407
      Location:1 → 658
      SEC63; Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14906.2

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