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    SRP40 Srp40p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRP40
    Official Full Name
    Srp40p
    Primary source
    SGD:S000001800
    Locus tag
    YKR092C
    See related
    AllianceGenome:SGD:S000001800; FungiDB:YKR092C; VEuPathDB:YKR092C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in nucleocytoplasmic transport. Located in nucleolus. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRP40 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (612665..613885, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Pxl1p Neighboring gene DNA-binding protein SRL3 Neighboring gene Ptr2p Neighboring gene ubiquitin-ribosomal 60S subunit protein L40B fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing in exon 9 of glucocorticoid receptor pre-mRNA is regulated by SRp40. Yan XB, et al. Mol Biol Rep, 2010 Mar. PMID 19343537
    2. Comparison of the rat nucleolar protein nopp140 with its yeast homolog SRP40. Differential phosphorylation in vertebrates and yeast. Meier UT. J Biol Chem, 1996 Aug 9. PMID 8702624
    3. The Srp40 protein plays a dose-sensitive role in preribosome assembly or transport and depends on its carboxy-terminal domain for proper localization to the yeast nucleoskeleton. Ikonomova R, et al. DNA Cell Biol, 1997 Oct. PMID 9364927
    4. Interactions between three common subunits of yeast RNA polymerases I and III. Lalo D, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 8516295, Free PMC Article
    5. Genetic interaction between a chaperone of small nucleolar ribonucleoprotein particles and cytosolic serine hydroxymethyltransferase. Yang Y, et al. J Biol Chem, 2003 Jun 27. PMID 12700234

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Srp40p
    NP_013018.3
    • Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      612665..613885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179882.3 → NP_013018.3  TPA: Srp40p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013018.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXF2, P32583
      Conserved Domains (1) summary
      pfam05022
      Location:334 → 404
      SRP40_C; SRP40, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32583.2

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