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    FBA1 fructose-bisphosphate aldolase FBA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FBA1
    Official Full Name
    fructose-bisphosphate aldolase FBA1
    Primary source
    SGD:S000001543
    Locus tag
    YKL060C
    See related
    AllianceGenome:SGD:S000001543; FungiDB:YKL060C; VEuPathDB:YKL060C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LOT1
    Summary
    Enables fructose-bisphosphate aldolase activity and melatonin binding activity. Involved in gluconeogenesis and glycolytic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FBA1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (326408..327487, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene stress-responsive transcriptional activator MSN4 Neighboring gene Bli1p Neighboring gene cleavage polyadenylation factor subunit MPE1 Neighboring gene transcription initiation factor IIA subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Study of purified aldolase from Saccharomyces cerevisiae, using irradiated fructose-1,6-diphosphate]. Rabega C, et al. Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol, 1976 Jan-Mar. PMID 133446
    2. Comparative properties of yeast and muscle aldolase. RICHARDS OC, et al. J Biol Chem, 1961 Dec. PMID 14491940
    3. Studies on the mechanism on the aldolase reaction; isotope exchange reactions of muscle and yeast aldolase. ROSE IA, et al. J Biol Chem, 1958 Mar. PMID 13538971
    4. Saccharomyces cerevisiae aldolase mutants. Lobo Z. J Bacteriol, 1984 Oct. PMID 6384192, Free PMC Article
    5. Role of mono- and divalent metal cations in the catalysis by yeast aldolase. Kadonaga JT, et al. Biochemistry, 1983 Jan 4. PMID 6338913

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S-glutathionylation of fructose-1,6-bisphosphate aldolase confers nitrosative stress tolerance on yeast cells via a metabolic switch.
      Title: S-glutathionylation of fructose-1,6-bisphosphate aldolase confers nitrosative stress tolerance on yeast cells via a metabolic switch.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-bisphosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-bisphosphate aldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables melatonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase FBA1
    NP_012863.1
    • Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      326408..327487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179626.1 → NP_012863.1  TPA: fructose-bisphosphate aldolase FBA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXM7, P14540
      UniProtKB/TrEMBL
      B3LR31, N1P7U8
      Conserved Domains (1) summary
      TIGR01520
      Location:3 → 359
      FruBisAldo_II_A; fructose-bisphosphate aldolase, class II, yeast/E. coli subtype
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14540.3

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