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    ACP1 acyl carrier protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ACP1
    Official Full Name
    acyl carrier protein
    Primary source
    SGD:S000001675
    Locus tag
    YKL192C
    See related
    AllianceGenome:SGD:S000001675; FungiDB:YKL192C; VEuPathDB:YKL192C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable acyl binding activity and acyl carrier activity. Involved in iron-sulfur cluster assembly and lipoate biosynthetic process. Located in mitochondrion. Part of mitochondrial [2Fe-2S] assembly complex. Orthologous to human NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ACP1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (80160..80537, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene threonine--tRNA ligase MST1 Neighboring gene type 1 protein phosphatase-activating protein SDS22 Neighboring gene 2-(3-amino-3-carboxypropyl)histidine synthase Neighboring gene calcineurin regulatory subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different respiratory-defective phenotypes of Neurospora crassa and Saccharomyces cerevisiae after inactivation of the gene encoding the mitochondrial acyl carrier protein. Schneider R, et al. Curr Genet, 1995 Dec. PMID 8595652
    2. A GX(2)GX(3)G motif facilitates acyl chain sequestration by Saccharomyces cerevisiae acyl carrier protein. Garima, et al. J Biol Chem, 2021 Dec. PMID 34767798, Free PMC Article
    3. Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae. Brody S, et al. FEBS Lett, 1997 May 19. PMID 9187370
    4. A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein. Stuible HP, et al. J Biol Chem, 1998 Aug 28. PMID 9712852
    5. Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs). Rossini E , et al. Chem Commun (Camb), 2018 Oct 11. PMID 30264077

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A GX2GX3G motif facilitates acyl chain sequestration by Saccharomyces cerevisiae acyl carrier protein.
      Title: A GX(2)GX(3)G motif facilitates acyl chain sequestration by Saccharomyces cerevisiae acyl carrier protein.
    2. ACP acylation is an acetyl-CoA-dependent modification required for electron transport chain assembly.
      Title: ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly.
    3. This work provides analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases. Perturbations of domain-domain interactions impact the function of type I fatty acid synthases. Identified are interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain-domain binding energetics.
      Title: Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).
    4. In this study, the authors demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in mitochondrial fatty acid synthesis (FASII), plays an unexpected and evolutionarily conserved role in iron sulfur cluster biogenesis.
      Title: The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyl binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl carrier activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial [2Fe-2S] assembly complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl carrier protein
    NP_012729.1
    • Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; coordinates mitochondrial fatty acid and iron sulfur cluster metabolism; activated by phosphopantetheinylation catalyzed by Ppt2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      80160..80537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179758.1 → NP_012729.1  TPA: acyl carrier protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX08, P32463
      UniProtKB/TrEMBL
      A6ZZD3, B3LQR3, C7GJ17, C8ZBY4, G2WHK0, N1P0Z9
      Conserved Domains (1) summary
      TIGR00517
      Location:46 → 122
      acyl_carrier; acyl carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32463.1

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