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    CHS6 Chs6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CHS6
    Official Full Name
    Chs6p
    Primary source
    SGD:S000003635
    Locus tag
    YJL099W
    See related
    AllianceGenome:SGD:S000003635; FungiDB:YJL099W; VEuPathDB:YJL099W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CSD3
    Summary
    Involved in Golgi to plasma membrane transport and chitin biosynthetic process. Located in trans-Golgi network transport vesicle. Part of exomer complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CHS6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (239414..241654)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene glutamate--cysteine ligase Neighboring gene 1-phosphatidylinositol 4-kinase LSB6 Neighboring gene Sap185p Neighboring gene enoyl-CoA hydratase PHS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae. Ziman M, et al. Mol Biol Cell, 1998 Jun. PMID 9614194, Free PMC Article
    2. Compromised chitin synthesis in lager yeast affects its Congo red resistance and release of mannoproteins from the cells. Omura F, et al. FEMS Microbiol Lett, 2020 Dec 14. PMID 33175116
    3. G-rich VEGF aptamer as a potential inhibitor of chitin trafficking signal in emerging opportunistic yeast infection. Vahed M, et al. Comput Biol Chem, 2019 Jun. PMID 30965174
    4. CSD2, CSD3, and CSD4, genes required for chitin synthesis in Saccharomyces cerevisiae: the CSD2 gene product is related to chitin synthases and to developmentally regulated proteins in Rhizobium species and Xenopus laevis. Bulawa CE. Mol Cell Biol, 1992 Apr. PMID 1532231, Free PMC Article
    5. Clathrin functions in the absence of the terminal domain binding site for adaptor-associated clathrin-box motifs. Collette JR, et al. Mol Biol Cell, 2009 Jul. PMID 19458198, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    part_of exomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exomer complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chs6p
    NP_012436.1
    • Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      239414..241654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181532.1 → NP_012436.1  TPA: Chs6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW85, P40955
      UniProtKB/TrEMBL
      B3LQ14, B5VL73, N1P321
      Conserved Domains (1) summary
      pfam09295
      Location:89 → 558
      ChAPs; ChAPs (Chs5p-Arf1p-binding proteins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40955.1

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