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    RPI1 Rpi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPI1
    Official Full Name
    Rpi1p
    Primary source
    SGD:S000001381
    Locus tag
    YIL119C
    See related
    AllianceGenome:SGD:S000001381; FungiDB:YIL119C; VEuPathDB:YIL119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase regulator activity. Involved in Ras protein signal transduction; fungal-type cell wall biogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPI1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (136654..137877, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene cation transporter Neighboring gene multidrug transporter Neighboring gene Rho family GTPase RHO3 Neighboring gene pheromone-regulated protein PRM5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network. Chin BL, et al. Genetics, 2012 Dec. PMID 23051644, Free PMC Article
    2. Critical role of RPI1 in the stress tolerance of yeast during ethanolic fermentation. Puria R, et al. FEMS Yeast Res, 2009 Dec. PMID 19678848
    3. Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function. Kim JH, et al. Mol Cell Biol, 1991 Aug. PMID 1649384, Free PMC Article
    4. Adaptability of the Saccharomyces cerevisiae yeasts to wine fermentation conditions relies on their strong ability to consume nitrogen. Brice C, et al. PLoS One, 2018. PMID 29432462, Free PMC Article
    5. Yeast Rpi1 is a putative transcriptional regulator that contributes to preparation for stationary phase. Sobering AK, et al. Eukaryot Cell, 2002 Feb. PMID 12455971, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rpi1p
    NP_012147.3
    • Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      136654..137877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179467.3 → NP_012147.3  TPA: Rpi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012147.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVG8, E9P8U9, P23250
      UniProtKB/TrEMBL
      C7GWJ1, N1P0V6
      Conserved Domains (1) summary
      pfam13837
      Location:95 → 157
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23250.2

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