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    RHO3 Rho family GTPase RHO3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RHO3
    Official Full Name
    Rho family GTPase RHO3
    Primary source
    SGD:S000001380
    Locus tag
    YIL118W
    See related
    AllianceGenome:SGD:S000001380; FungiDB:YIL118W; VEuPathDB:YIL118W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTP binding activity and GTPase activity. Involved in establishment or maintenance of actin cytoskeleton polarity; positive regulation of exocytosis; and positive regulation of formin-nucleated actin cable assembly. Located in cellular bud and cytosol. Orthologous to several human genes including RND1 (Rho family GTPase 1); RND2 (Rho family GTPase 2); and RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RHO3 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (139752..140447)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene multidrug transporter Neighboring gene Rpi1p Neighboring gene pheromone-regulated protein PRM5 Neighboring gene histidinol-phosphate transaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions of the Trichoderma reesei rho3 with the secretory pathway in yeast and T. reesei. Vasara T, et al. Mol Microbiol, 2001 Dec. PMID 11886564
    2. Trichoderma reesei rho3 a homologue of yeast RH03 suppresses the growth defect of yeast sec15-1 mutation. Vasara T, et al. Curr Genet, 2001 Sep. PMID 11680821
    3. Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae. Matsui Y, et al. Gene, 1992 May 1. PMID 1587484
    4. Evidence for specific interaction between the RhoGAP domain from the yeast Rgd1 protein and phosphoinositides. Odaert B, et al. Biochem Biophys Res Commun, 2011 Feb 4. PMID 21215255
    5. Crystal structure of the S.cerevisiae exocyst component Exo70p. Hamburger ZA, et al. J Mol Biol, 2006 Feb 10. PMID 16359701

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
      Title: The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
    2. Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
      Title: Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
    3. The authors propose that Tos2p, a protein involved in polarized growth and most probably associated with the plasma membrane, modulates the action of Rgd1p and Rho3p in Saccharomyces cerevisiae.
      Title: Evidence for functional links between the Rgd1-Rho3 RhoGAP-GTPase module and Tos2, a protein involved in polarized growth in Saccharomyces cerevisiae.
    4. a small region at the N terminus is necessary and sufficient to confer Rho3 localization and function onto Cdc42
      Title: The function of two Rho family GTPases is determined by distinct patterns of cell surface localization.
    5. Data show that Exo70 has the biochemical properties expected of a direct effector for both Rho3 and Cdc42, and suggest that interaction with the Exo70 component of the exocyst is a key event in spatial regulation of exocytosis by Rho GTPases.
      Title: The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis.
    6. The ability of Rho3 and Cdc42 to hydrolyze GTP is not required for their role in secretion.
      Title: Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.
    7. Wsc1p participates in the regulation of a Rho3/4-dependent cellular mechanism.
      Title: The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho family GTPase RHO3
    NP_012148.1
    • Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      139752..140447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179466.1 → NP_012148.1  TPA: Rho family GTPase RHO3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012148.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVG9, Q00245
      UniProtKB/TrEMBL
      A6ZVF9, B3LTW5, B5VKJ1, C8ZAC6, G2WG33, N1P9A6
      Conserved Domains (1) summary
      cd04134
      Location:17 → 231
      Rho3; Ras homology family 3 (Rho3) of small guanosine triphosphatases (GTPases)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00245.2

    Gene LinkOut

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