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    NUP159 FG-nucleoporin NUP159 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUP159
    Official Full Name
    FG-nucleoporin NUP159
    Primary source
    SGD:S000001377
    Locus tag
    YIL115C
    See related
    AllianceGenome:SGD:S000001377; FungiDB:YIL115C; VEuPathDB:YIL115C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NUP158; RAT7
    Summary
    Enables adenyl-nucleotide exchange factor activity. A structural constituent of nuclear pore. Involved in nuclear pore localization and nucleocytoplasmic transport. Part of nuclear pore central transport channel and nuclear pore cytoplasmic filaments. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUP159 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (144327..148709, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene pheromone-regulated protein PRM5 Neighboring gene histidinol-phosphate transaminase Neighboring gene putative porin POR2 Neighboring gene mitogen-activated protein kinase tyrosine protein phosphatase SDP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate. Kraemer DM, et al. J Biol Chem, 1995 Aug 11. PMID 7642562
    2. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes. Gorsch LC, et al. J Cell Biol, 1995 May. PMID 7744966, Free PMC Article
    3. NMR based solvent exchange experiments to understand the conformational preference of intrinsically disordered proteins using FG-nucleoporin peptide as a model. Heisel KA, et al. Biopolymers, 2014 Jan. PMID 24037535, Free PMC Article
    4. A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae. Del Priore V, et al. J Cell Sci, 1997 Dec. PMID 9359887
    5. Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts. Hilleren P, et al. RNA, 2001 May. PMID 11350039, Free PMC Article

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biophysical characterization of the interaction of Atg8 with a disordered region of Nup159 involved in selective autophagy of the nuclear pore complex.
      Title: Biophysical characterization of the interaction of Atg8 with a disordered region of Nup159 involved in selective autophagy of the nuclear pore complex.
    2. TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes.
      Title: TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes.
    3. Nup159 is an Atg8-interacting motif-dependent Atg8 receptor.
      Title: Selective autophagy degrades nuclear pore complexes.
    4. Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly
      Title: Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly.
    5. Data indicate that the comparative binding of Dyn2 to two Nup159 target sites shows similar affinities (18 and 13 muM), but divergent thermal binding modes.
      Title: Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction.
    6. the Nup159 NTD functions in mRNA export as a binding platform, tethering shuttling Dbp5 molecules at the nuclear periphery
      Title: The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore cytoplasmic filaments IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FG-nucleoporin NUP159
    NP_012151.1
    • FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      144327..148709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179463.1 → NP_012151.1  TPA: FG-nucleoporin NUP159 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVH2, P40477
      UniProtKB/TrEMBL
      B3LTW2
      Conserved Domains (5) summary
      PTZ00395
      Location:558 → 874
      PTZ00395; Sec24-related protein; Provisional
      COG5271
      Location:892 → 1163
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      COG5651
      Location:142 → 673
      COG5651; PPE-repeat protein [Function unknown]
      PRK08581
      Location:751 → 1006
      PRK08581; amidase domain-containing protein
      pfam16755
      Location:24 → 380
      NUP214; Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40477.1

    Gene LinkOut

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