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    WIP1 Wip1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 3799971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WIP1
    Official Full Name
    Wip1p
    Primary source
    SGD:S000113553
    Locus tag
    YDR374W-A
    See related
    AllianceGenome:SGD:S000113553; FungiDB:YDR374W-A; VEuPathDB:YDR374W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables centromeric DNA binding activity. Involved in chromosome segregation. Located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See WIP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1224757..1225026)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene frequenin Neighboring gene mRNA-binding phosphate metabolism regulator Neighboring gene bifunctional AAA family ATPase chaperone/translocase BCS1 Neighboring gene NADPH-adrenodoxin reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex. Zhang Z, et al. Nucleic Acids Res, 2020 Nov 4. PMID 32976599, Free PMC Article
    2. A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination. Kuhl LM, et al. Genetics, 2020 Oct. PMID 32843356, Free PMC Article
    3. The kinetochore prevents centromere-proximal crossover recombination during meiosis. Vincenten N, et al. Elife, 2015 Dec 14. PMID 26653857, Free PMC Article
    4. The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T. Hinshaw SM, et al. Curr Biol, 2020 Sep 7. PMID 32679099
    5. Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Cliften P, et al. Science, 2003 Jul 4. PMID 12775844

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables centromeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Wip1p
    NP_001032576.1
    • Kinetochore localized hypothetical protein; interacts with Cnn1p (CENP-T); orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-W and fission yeast new1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1224757..1225026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184680.1 → NP_001032576.1  TPA: Wip1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_001032576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT06, Q2V2P8
      UniProtKB/TrEMBL
      A6ZYX3, B3LFS8, C7GMG2, C8Z5T7, G2WBB1, N1P727
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2V2P8.1

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