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    ADK1 adenylate kinase ADK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ADK1
    Official Full Name
    adenylate kinase ADK1
    Primary source
    SGD:S000002634
    Locus tag
    YDR226W
    See related
    AllianceGenome:SGD:S000002634; FungiDB:YDR226W; VEuPathDB:YDR226W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AKY1; AKY2
    Summary
    Enables DNA replication origin binding activity and adenylate kinase activity. Involved in ADP biosynthetic process; DNA replication initiation; and pre-replicative complex assembly. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (916486..917154)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene chromatin-silencing protein SIR4 Neighboring gene Pcf11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP:AMP phosphotransferase from baker's yeast. Purification and properties. Ito Y, et al. Eur J Biochem, 1980 Mar. PMID 6245882
    2. Two parameters improve efficiency of mitochondrial uptake of adenylate kinase: decreased folding velocity and increased propensity of N-terminal alpha-helix formation. Angermayr M, et al. FEBS Lett, 2001 Nov 23. PMID 11728466
    3. Competition of spontaneous protein folding and mitochondrial import causes dual subcellular location of major adenylate kinase. Strobel G, et al. Mol Biol Cell, 2002 May. PMID 12006643, Free PMC Article
    4. Cytoplasmic and mitochondrial forms of yeast adenylate kinase 2 are N-acetylated. Klier H, et al. Biochim Biophys Acta, 1996 Apr 26. PMID 8639701
    5. Identification and characterization of a yeast gene encoding an adenylate kinase homolog. Konrad M. Biochim Biophys Acta, 1993 Feb 20. PMID 8439550

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adk1p regulates ATP metabolism on pre-RC proteins to promote pre-RC assembly and activation.
      Title: ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ADP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-replicative complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase ADK1
    NP_010512.1
    • Adenylate kinase, required for purine metabolism; controls ATP homeostasis; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      916486..917154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180534.1 → NP_010512.1  TPA: adenylate kinase ADK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZYI0, B3LG61, D6VSK8, P07170, Q6Q539
      UniProtKB/TrEMBL
      C7GVC6, C8Z5D7, G2WAX1, N1P6W0
      Conserved Domains (1) summary
      PRK00279
      Location:8 → 221
      adk; adenylate kinase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07170.2

    Gene LinkOut

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