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    SRO9 Sro9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRO9
    Official Full Name
    Sro9p
    Primary source
    SGD:S000000542
    Locus tag
    YCL037C
    See related
    AllianceGenome:SGD:S000000542; FungiDB:YCL037C; VEuPathDB:YCL037C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in regulation of translation. Located in cytoplasmic stress granule. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator) and LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRO9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (57374..58678, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene glucose-induced degradation complex subunit GID7 Neighboring gene Atg22p Neighboring gene Gfd2p Neighboring gene dithiol glutaredoxin GRX1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae. Pandita M, et al. J Biochem Mol Toxicol, 2021 Jul. PMID 33797855
    2. Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. Tsukada M, et al. J Cell Sci, 1996 Oct. PMID 8923208
    3. Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Sobel SG, et al. Mol Biol Cell, 1999 Nov. PMID 10564276, Free PMC Article
    4. Multiple mechanisms of suppression circumvent transcription defects in an RNA polymerase mutant. Tan Q, et al. Mol Cell Biol, 2000 Nov. PMID 11027282, Free PMC Article
    5. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs. Jennings MD, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37070186, Free PMC Article

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
      Title: Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
    2. Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae.
      Title: Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sro9p
    NP_009893.2
    • Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; role in preventing L-A mycovirus pathogenesis; SRO9 has a paralog, SLF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      57374..58678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178682.1 → NP_009893.2  TPA: Sro9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009893.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQX8, P25567
      UniProtKB/TrEMBL
      A6ZTF3, B3LU45, C7GSZ4, C8Z452, G2W9Y8, N1P984
      Conserved Domains (1) summary
      COG5193
      Location:1 → 434
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25567.2

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