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    TAT1 amino acid transporter TAT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TAT1
    Official Full Name
    amino acid transporter TAT1
    Primary source
    SGD:S000000273
    Locus tag
    YBR069C
    See related
    AllianceGenome:SGD:S000000273; FungiDB:YBR069C; VEuPathDB:YBR069C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TAP1; VAP1
    Summary
    Enables low-affinity tryptophan transmembrane transporter activity. Involved in transmembrane transport; tryptophan transport; and tyrosine transport. Located in plasma membrane. Orthologous to human SLC7A4 (solute carrier family 7 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TAT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (376574..378433, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative lipase Neighboring gene branched-chain amino acid permease BAP2 Neighboring gene ncRNA Neighboring gene N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TAT1 encodes a low-affinity histidine transporter in Saccharomyces cerevisiae. Bajmoczi M, et al. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473505
    2. Volatile anesthetics affect nutrient availability in yeast. Palmer LK, et al. Genetics, 2002 Jun. PMID 12072454, Free PMC Article
    3. Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. He C, et al. PLoS Genet, 2014 Dec. PMID 25521617, Free PMC Article
    4. Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Schmidt A, et al. Mol Cell Biol, 1994 Oct. PMID 7523855, Free PMC Article
    5. The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Heitman J, et al. Mol Cell Biol, 1993 Aug. PMID 7687745, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
      Title: Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
    2. Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
      Title: Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
    3. A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
      Title: A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
    4. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
      Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
    5. Tup1p bound to the promoter region of TAT1 and TAT2 genes that were dependent on STP1 and STP2 (encoding DNA-binding activator proteins) for expression.
      Title: Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables low-affinity tryptophan transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tyrosine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amino acid transporter TAT1
    NP_009625.1
    • Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      376574..378433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178417.1 → NP_009625.1  TPA: amino acid transporter TAT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ68, P38085
      UniProtKB/TrEMBL
      G2W974, N1P8B9
      Conserved Domains (1) summary
      TIGR00913
      Location:91 → 567
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38085.1

    Gene LinkOut

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